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Noninvasive Measurement of Microvascular Leakage in Patients with Dengue Hemorrhagic Fever

Clinical infectious diseases, 2001-01, Vol.32 (2), p.243-253 [Peer Reviewed Journal]

Copyright 2001 The Infectious Diseases Society of America ;2001 by the Infectious Diseases Society of America 2001 ;2001 INIST-CNRS ;ISSN: 1058-4838 ;EISSN: 1537-6591 ;DOI: 10.1086/318453 ;PMID: 11170914 ;CODEN: CIDIEL

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Title:
Noninvasive Measurement of Microvascular Leakage in Patients with Dengue Hemorrhagic Fever
Author: Bethell, Delia B. ; Gamble, John ; Loc, Pham Phu ; Dung, Nguyen Minh ; Chau, Tran Thi Hong ; Loan, Ha Thi ; Thuy, Tran Thi Nhu ; Tam, Dong Thi Hoai ; Gartside, Ivor B. ; White, Nicholas J. ; Day, Nicholas P. J.
Subjects: Adolescent ; Arboviral haemorrhagic fevers ; Arboviroses ; Biological and medical sciences ; Blood flow ; Capillaries ; Capillaries - physiopathology ; Capillary Permeability ; Child ; Child, Preschool ; Children ; Colloids ; Dengue ; Dengue hemorrhagic fever ; Dengue virus ; Female ; Fluid Therapy ; Hospital admissions ; Human viral diseases ; Humans ; Infectious diseases ; Major Article ; Male ; Medical sciences ; Microcirculation - physiopathology ; Osmosis ; Plethysmography ; Resuscitation ; Severe Dengue - physiopathology ; Severe Dengue - therapy ; Strain gauges ; Tropical viral diseases ; Viral diseases
Is Part Of: Clinical infectious diseases, 2001-01, Vol.32 (2), p.243-253
Description: Dengue shock syndrome (DSS) is a potentially lethal complication of dengue virus infection associated with hypotension and leakage of plasma water into the extravascular space. To determine whether the underlying pathophysiology of DSS is distinct from that in milder forms of the disease, we assessed microvascular permeability, by use of strain gauge plethysmography, in Vietnamese children with DSS (n = 19), or dengue hemorrhagic fever (DHF) without shock (n = 16), and in healthy control children (n = 15). At admission and after fluid resuscitation, the mean coefficient of microvascular permeability (Kf) for the patients with dengue was ∼50% higher than that for the control patients (P = .02). There was no significant difference in Kf between the 2 groups of patients with dengue; this suggests the same underlying pathophysiology. We hypothesize that in patients with DSS, the fluctuations in Kf are larger than those in patients with DHF, which leads to short-lived peaks of markedly increased microvascular permeability and consequent hemodynamic shock.
Publisher: Chicago, IL: The University of Chicago Press
Language: English
Identifier: ISSN: 1058-4838
EISSN: 1537-6591
DOI: 10.1086/318453
PMID: 11170914
CODEN: CIDIEL
Source: MEDLINE
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Noninvasive Measurement of Microvascular Leakage in Patients with Dengue Hemorrhagic Fever

Copyright 2001 The Infectious Diseases Society of America ;2001 by the Infectious Diseases Society of America 2001 ;2001 INIST-CNRS ;ISSN: 1058-4838 ;EISSN: 1537-6591 ;DOI: 10.1086/318453 ;PMID: 11170914 ;CODEN: CIDIEL

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