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Comparative cellular analysis of motor cortex in human, marmoset and mouse

Nature (London), 2021-10, Vol.598 (7879), p.111-119 [Peer Reviewed Journal]

2021. The Author(s). ;Copyright Nature Publishing Group Oct 7, 2021 ;The Author(s) 2021, corrected publication 2022 ;ISSN: 0028-0836 ;ISSN: 1476-4687 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-021-03465-8 ;PMID: 34616062

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Title:
Comparative cellular analysis of motor cortex in human, marmoset and mouse
Author: Bakken, Trygve E ; Jorstad, Nikolas L ; Hu, Qiwen ; Lake, Blue B ; Kalmbach, Brian E ; Crow, Megan ; Hodge, Rebecca D ; Krienen, Fenna M ; Sorensen, Staci A ; Eggermont, Jeroen ; Yao, Zizhen ; Aevermann, Brian D ; Aldridge, Andrew I ; Bartlett, Anna ; Bertagnolli, Darren ; Casper, Tamara ; Castanon, Rosa G ; Crichton, Kirsten ; Dalley, Rachel ; Dee, Nick ; Dembrow, Nikolai ; Diep, Dinh ; Ding, Song-Lin ; Dong, Weixiu ; Fang, Rongxin ; Fischer, Stephan ; Goldy, Jeff ; Graybuck, Lucas T ; Herb, Brian R ; Hou, Xiaomeng ; Kancherla, Jayaram ; Kroll, Matthew ; Lathia, Kanan ; van Lew, Baldur ; Li, Yang Eric ; Liu, Christine S ; Liu, Hanqing ; Lucero, Jacinta D ; Mahurkar, Anup ; McMillen, Delissa ; Miller, Jeremy A ; Moussa, Marmar ; Nery, Joseph R ; Nicovich, Philip R ; Niu, Sheng-Yong ; Orvis, Joshua ; Osteen, Julia K ; Owen, Scott ; Palmer, Carter R ; Pham, Thanh ; Plongthongkum, Nongluk ; Poirion, Olivier ; Rimorin, Christine ; Rivkin, Angeline ; Romanow, William J ; Sedeño-Cortés, Adriana E ; Siletti, Kimberly ; Somasundaram, Saroja ; Sulc, Josef ; Tieu, Michael ; Torkelson, Amy ; Tung, Herman ; Xie, Fangming ; Yanny, Anna Marie ; Zhang, Renee ; Ament, Seth A ; Behrens, M Margarita ; Bravo, Hector Corrada ; Chun, Jerold ; Dobin, Alexander ; Gillis, Jesse ; Hertzano, Ronna ; Hof, Patrick R ; Höllt, Thomas ; Horwitz, Gregory D ; Keene, C Dirk ; Kharchenko, Peter V ; Lelieveldt, Boudewijn P ; Luo, Chongyuan ; Mukamel, Eran A ; Pinto-Duarte, António ; Preissl, Sebastian ; Regev, Aviv ; Ren, Bing ; Scheuermann, Richard H ; Smith, Kimberly ; Spain, William J ; White, Owen R ; Koch, Christof ; Hawrylycz, Michael ; Tasic, Bosiljka ; Macosko, Evan Z ; McCarroll, Steven A ; Ting, Jonathan T ; Zeng, Hongkui ; Zhang, Kun ; Feng, Guoping ; Ecker, Joseph R ; Linnarsson, Sten ; Lein, Ed S
Subjects: Adaptations ; Animals ; Atlases as Topic ; Callithrix - genetics ; Chromatin ; Classification ; Conservation ; Cortex (motor) ; Datasets ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Epigenesis, Genetic ; Epigenomics ; Female ; GABAergic Neurons - cytology ; GABAergic Neurons - metabolism ; Gene expression ; Gene Expression Profiling ; Gene sequencing ; Genes ; Glutamates - metabolism ; Homology ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Medicin och hälsovetenskap ; Mice ; Middle Aged ; Motor Cortex - anatomy & histology ; Motor Cortex - cytology ; Motor task performance ; Neurons ; Neurons - classification ; Neurons - cytology ; Neurons - metabolism ; Organ Specificity ; Phylogeny ; Pyramidal tracts ; Regulatory mechanisms (biology) ; Single-Cell Analysis ; Species ; Species classification ; Species Specificity ; Taxonomy ; Transcriptome ; Transcriptomes ; Transcriptomics ; Wildlife conservation ; γ-Aminobutyric acid
Is Part Of: Nature (London), 2021-10, Vol.598 (7879), p.111-119
Description: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals . Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities that mirror evolutionary distance and are consistent between the transcriptome and epigenome. The core conserved molecular identities of neuronal and non-neuronal cell types allow us to generate a cross-species consensus classification of cell types, and to infer conserved properties of cell types across species. Despite the overall conservation, however, many species-dependent specializations are apparent, including differences in cell-type proportions, gene expression, DNA methylation and chromatin state. Few cell-type marker genes are conserved across species, revealing a short list of candidate genes and regulatory mechanisms that are responsible for conserved features of homologous cell types, such as the GABAergic chandelier cells. This consensus transcriptomic classification allows us to use patch-seq (a combination of whole-cell patch-clamp recordings, RNA sequencing and morphological characterization) to identify corticospinal Betz cells from layer 5 in non-human primates and humans, and to characterize their highly specialized physiology and anatomy. These findings highlight the robust molecular underpinnings of cell-type diversity in M1 across mammals, and point to the genes and regulatory pathways responsible for the functional identity of cell types and their species-specific adaptations.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
ISSN: 1476-4687
EISSN: 1476-4687
DOI: 10.1038/s41586-021-03465-8
PMID: 34616062
Source: ProQuest One Psychology
MEDLINE
SWEPUB Freely available online
ProQuest Central

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Comparative cellular analysis of motor cortex in human, marmoset and mouse

2021. The Author(s). ;Copyright Nature Publishing Group Oct 7, 2021 ;The Author(s) 2021, corrected publication 2022 ;ISSN: 0028-0836 ;ISSN: 1476-4687 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-021-03465-8 ;PMID: 34616062

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