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Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance

Cell, 2017-11, Vol.171 (5), p.1015-1028.e13 [Peer Reviewed Journal]

2017 ;Published by Elsevier Inc. ;ISSN: 0092-8674 ;ISSN: 1097-4172 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2017.09.016 ;PMID: 29056339

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Title:
Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance
Author: Rosshart, Stephan P. ; Vassallo, Brian G. ; Angeletti, Davide ; Hutchinson, Diane S. ; Morgan, Andrew P. ; Takeda, Kazuyo ; Hickman, Heather D. ; McCulloch, John A. ; Badger, Jonathan H. ; Ajami, Nadim J. ; Trinchieri, Giorgio ; Pardo-Manuel de Villena, Fernando ; Yewdell, Jonathan W. ; Rehermann, Barbara
Subjects: Animals ; Animals, Laboratory ; Animals, Wild ; bacteria ; Carcinogenesis ; Carcinogenesis - immunology ; classification ; colorectal cancer ; cytokine ; Disease Resistance ; Female ; Gastrointestinal Microbiome ; gut ; Immunologi inom det medicinska området ; immunology ; Immunology in the medical area ; Inbred C57BL ; inflammation ; influenza ; innate ; Laboratory ; Male ; Maryland ; Mice ; Mice - classification ; Mice - immunology ; Mice - microbiology ; Mice, Inbred C57BL ; microbiology ; Microbiology in the medical area ; microbiome ; Mikrobiologi inom det medicinska området ; Peromyscus ; virus ; Virus Diseases ; Virus Diseases - immunology ; Wild ; wild mouse
Is Part Of: Cell, 2017-11, Vol.171 (5), p.1015-1028.e13
Description: Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living mammals. Because the microbiome is a major factor in mammalian physiology, we aimed to identify a naturally evolved reference microbiome to better recapitulate physiological phenomena relevant in the natural world outside the laboratory. Among 21 distinct mouse populations worldwide, we identified a closely related wild relative to standard laboratory mouse strains. Its bacterial gut microbiome differed significantly from its laboratory mouse counterpart and was transferred to and maintained in laboratory mice over several generations. Laboratory mice reconstituted with natural microbiota exhibited reduced inflammation and increased survival following influenza virus infection and improved resistance against mutagen/inflammation-induced colorectal tumorigenesis. By demonstrating the host fitness-promoting traits of natural microbiota, our findings should enable the discovery of protective mechanisms relevant in the natural world and improve the modeling of complex diseases of free-living mammals. [Display omitted] [Display omitted] •Wild mice from Maryland are close relatives to standard laboratory mouse strains•Gut microbiota of wild mice and laboratory mice differ significantly•Wild mouse gut microbiota can be banked and maintained in a laboratory mouse colony•Natural gut microbiota improves outcome in viral infection and tumorigenesis models Characterization of a wild mice reference microbiome opens a window of opportunity to understand how the gut microbiota affects aspects of host physiology that are important in the natural world outside the laboratory.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0092-8674
ISSN: 1097-4172
EISSN: 1097-4172
DOI: 10.1016/j.cell.2017.09.016
PMID: 29056339
Source: Cell Press Free Archives
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Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance

2017 ;Published by Elsevier Inc. ;ISSN: 0092-8674 ;ISSN: 1097-4172 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2017.09.016 ;PMID: 29056339

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