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Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning

Cell, 2019-06, Vol.178 (1), p.60-75.e19 [Peer Reviewed Journal]

2019 Elsevier Inc. ;Copyright © 2019 Elsevier Inc. All rights reserved. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2019.05.040 ;PMID: 31230716

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Title:
Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning
Author: Handler, Annie ; Graham, Thomas G.W. ; Cohn, Raphael ; Morantte, Ianessa ; Siliciano, Andrew F. ; Zeng, Jianzhi ; Li, Yulong ; Ruta, Vanessa
Subjects: Animals ; Association Learning - physiology ; associative learning ; Behavior, Animal - physiology ; Conditioning, Classical - physiology ; dopamine ; Dopamine - metabolism ; Dopaminergic Neurons - metabolism ; Drosophila ; Drosophila - physiology ; Drosophila Proteins - metabolism ; G-protein second messengers ; memory ; Mushroom Bodies - physiology ; mushroom body ; Neuronal Plasticity ; Odorants ; olfaction ; Receptors, Dopamine - metabolism ; Receptors, Dopamine D1 - metabolism ; Reward ; Smell - physiology ; synaptic plasticity ; Synaptic Potentials - physiology ; Time Factors
Is Part Of: Cell, 2019-06, Vol.178 (1), p.60-75.e19
Description: Animals rely on the relative timing of events in their environment to form and update predictive associations, but the molecular and circuit mechanisms for this temporal sensitivity remain incompletely understood. Here, we show that olfactory associations in Drosophila can be written and reversed on a trial-by-trial basis depending on the temporal relationship between an odor cue and dopaminergic reinforcement. Through the synchronous recording of neural activity and behavior, we show that reversals in learned odor attraction correlate with bidirectional neural plasticity in the mushroom body, the associative olfactory center of the fly. Two dopamine receptors, DopR1 and DopR2, contribute to this temporal sensitivity by coupling to distinct second messengers and directing either synaptic depression or potentiation. Our results reveal how dopamine-receptor signaling pathways can detect the order of events to instruct opposing forms of synaptic and behavioral plasticity, allowing animals to flexibly update their associations in a dynamic environment. [Display omitted] •The timing of odor and dopaminergic reinforcement instructs opposing associations•Bidirectional plasticity in the mushroom body correlates with these learned behaviors•Distinct DopR1 and DopR2 signaling cascades exhibit different temporal sensitivity•Behavioral and neural plasticity depend on the balance of DopR1 and DopR2 signaling Olfactory associations are formed and updated on a trial-by-trial basis depending on the timing of the odor presentation and reinforcement mediated by two dopamine receptor signaling pathways that play opposing roles in directing synaptic and behavioral plasticity in Drosophila.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0092-8674
EISSN: 1097-4172
DOI: 10.1016/j.cell.2019.05.040
PMID: 31230716
Source: Cell Press Free Archives
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Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning

2019 Elsevier Inc. ;Copyright © 2019 Elsevier Inc. All rights reserved. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2019.05.040 ;PMID: 31230716

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