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Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations

Cancer cell, 2022-01, Vol.40 (1), p.26-35 [Peer Reviewed Journal]

2021 The Authors ;Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. ;ISSN: 1535-6108 ;EISSN: 1878-3686 ;DOI: 10.1016/j.ccell.2021.12.004 ;PMID: 34951956

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  • Title:
    Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations
  • Author: Letai, Anthony ; Bhola, Patrick ; Welm, Alana L.
  • Subjects: Biomarkers, Tumor - genetics ; functional precision medicine ; Humans ; Medical Oncology - methods ; Mutation - genetics ; Neoplasms - therapy ; patient-derived models ; Pharmaceutical Preparations - metabolism ; Precision medicine ; Precision Medicine - methods ; precision oncology
  • Is Part Of: Cancer cell, 2022-01, Vol.40 (1), p.26-35
  • Description: Functional precision medicine is a strategy whereby live tumor cells from affected individuals are directly perturbed with drugs to provide immediately translatable, personalized information to guide therapy. The heterogeneity of human cancer has led to the realization that personalized approaches are needed to improve treatment outcomes. Precision oncology has traditionally used static features of the tumor to dictate which therapies should be used. Static features can include expression of key targets or genomic analysis of mutations to identify therapeutically targetable “drivers.” Although a surprisingly small proportion of individuals derive clinical benefit from the static approach, functional precision medicine can provide additional information regarding tumor vulnerabilities. We discuss emerging technologies for functional precision medicine as well as limitations and challenges in using these assays in the clinical trials that will be necessary to determine whether functional precision medicine can improve outcomes and eventually become a standard tool in clinical oncology.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 1535-6108
    EISSN: 1878-3686
    DOI: 10.1016/j.ccell.2021.12.004
    PMID: 34951956
  • Source: Cell Press Free Archives
    MEDLINE
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