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Regenerative Approaches for the Treatment of Large Bone Defects

Tissue engineering. Part B, Reviews, 2021-12, Vol.27 (6), p.539-547 [Peer Reviewed Journal]

2021, Mary Ann Liebert, Inc., publishers ;Copyright Mary Ann Liebert, Inc. Dec 2021 ;Copyright 2021, Mary Ann Liebert, Inc., publishers 2021 Mary Ann Liebert, Inc., publishers ;ISSN: 1937-3368 ;EISSN: 1937-3376 ;DOI: 10.1089/ten.teb.2020.0281 ;PMID: 33138705

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  • Title:
    Regenerative Approaches for the Treatment of Large Bone Defects
  • Author: Stahl, Alexander ; Yang, Yunzhi Peter
  • Subjects: Autografts ; Bone and Bones ; Bone grafts ; Bone Transplantation ; Humans ; Orthopedics ; Review ; Review Articles ; Skin & tissue grafts ; Surgical techniques ; Tissue engineering ; Tissue Engineering - methods ; Vascularization
  • Is Part Of: Tissue engineering. Part B, Reviews, 2021-12, Vol.27 (6), p.539-547
  • Description: A variety of engineered materials have gained acceptance in orthopedic practice as substitutes for autologous bone grafts, although the regenerative efficacy of these engineered grafts is still limited compared with that of transplanted native tissues. For bone defects greater than 4–5 cm, however, common bone grafting procedures are insufficient and more complicated surgical interventions are required to repair and regenerate the damaged or missing bone. In this review, we describe current grafting materials and surgical techniques for the reconstruction of large bone defects, followed by tissue engineering (TE) efforts to develop improved therapies. Particular emphasis is placed on graft vascularization, because for both autologous bone and engineered alternatives, achieving adequate vascular development within the regenerating bone tissues remains a significant challenge in the context of large bone defects. To this end, TE and surgical strategies to induce development of a vasculature within bone grafts are discussed.
  • Publisher: United States: Mary Ann Liebert, Inc., publishers
  • Language: English
  • Identifier: ISSN: 1937-3368
    EISSN: 1937-3376
    DOI: 10.1089/ten.teb.2020.0281
    PMID: 33138705
  • Source: MEDLINE
    Alma/SFX Local Collection
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