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Cellular and molecular actors of myeloid cell fusion: podosomes and tunneling nanotubes call the tune

Cellular and molecular life sciences : CMLS, 2021-09, Vol.78 (17-18), p.6087-6104 [Peer Reviewed Journal]

The Author(s) 2021 ;2021. The Author(s). ;The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1420-682X ;EISSN: 1420-9071 ;DOI: 10.1007/s00018-021-03875-x ;PMID: 34296319

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Title:
Cellular and molecular actors of myeloid cell fusion: podosomes and tunneling nanotubes call the tune
Author: Dufrançais, Ophélie ; Mascarau, Rémi ; Poincloux, Renaud ; Maridonneau-Parini, Isabelle ; Raynaud-Messina, Brigitte ; Vérollet, Christel
Subjects: Actin ; Biochemistry ; Biomedical and Life Sciences ; Biomedical materials ; Biomedicine ; Bone turnover ; Cell Adhesion ; Cell Behavior ; Cell Biology ; Cell fusion ; Cell surface ; Cellular Biology ; Cytokines ; Genotype & phenotype ; Giant cells ; Giant Cells - cytology ; Giant Cells - metabolism ; Heterogeneity ; Homeostasis ; Humans ; Infections ; Inflammation ; Integrins - metabolism ; Laboratories ; Life Sciences ; Localization ; Macrophages ; Macrophages - cytology ; Macrophages - metabolism ; Monocytes ; Myeloid cells ; Myeloid Cells - cytology ; Myeloid Cells - metabolism ; Myeloid Cells - ultrastructure ; Nanotechnology ; Nanotubes ; Osteoclasts ; Osteoclasts - cytology ; Osteoclasts - metabolism ; Osteogenesis ; Physiology ; Podosomes - metabolism ; Receptors, Immunologic - metabolism ; Review ; Tunneling
Is Part Of: Cellular and molecular life sciences : CMLS, 2021-09, Vol.78 (17-18), p.6087-6104
Description: Different types of multinucleated giant cells (MGCs) of myeloid origin have been described; osteoclasts are the most extensively studied because of their importance in bone homeostasis. MGCs are formed by cell-to-cell fusion, and most types have been observed in pathological conditions, especially in infectious and non-infectious chronic inflammatory contexts. The precise role of the different MGCs and the mechanisms that govern their formation remain poorly understood, likely due to their heterogeneity. First, we will introduce the main populations of MGCs derived from the monocyte/macrophage lineage. We will then discuss the known molecular actors mediating the early stages of fusion, focusing on cell-surface receptors involved in the cell-to-cell adhesion steps that ultimately lead to multinucleation. Given that cell-to-cell fusion is a complex and well-coordinated process, we will also describe what is currently known about the evolution of F-actin-based structures involved in macrophage fusion, i.e., podosomes, zipper-like structures, and tunneling nanotubes (TNT). Finally, the localization and potential role of the key fusion mediators related to the formation of these F-actin structures will be discussed. This review intends to present the current status of knowledge of the molecular and cellular mechanisms supporting multinucleation of myeloid cells, highlighting the gaps still existing, and contributing to the proposition of potential disease-specific MGC markers and/or therapeutic targets.
Publisher: Cham: Springer International Publishing
Language: English
Identifier: ISSN: 1420-682X
EISSN: 1420-9071
DOI: 10.1007/s00018-021-03875-x
PMID: 34296319
Source: Hyper Article en Ligne (HAL) (Open Access)
MEDLINE
Springer Nature OA/Free Journals
ProQuest Central

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Cellular and molecular actors of myeloid cell fusion: podosomes and tunneling nanotubes call the tune

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