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Targeting apoptosis in cancer therapy

Nature reviews. Clinical oncology, 2020-07, Vol.17 (7), p.395-417 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;ISSN: 1759-4774 ;EISSN: 1759-4782 ;DOI: 10.1038/s41571-020-0341-y ;PMID: 32203277

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Title:
Targeting apoptosis in cancer therapy
Author: Carneiro, Benedito A ; El-Deiry, Wafik S
Subjects: Apoptosis ; Apoptosis - genetics ; Bioavailability ; Cancer ; Care and treatment ; Cell death ; Cellular signal transduction ; Cellular stress response ; DNA damage ; DNA Damage - genetics ; Drug Resistance, Neoplasm - genetics ; Enzyme inhibitors ; Health aspects ; Humans ; Immunosurveillance ; Molecular Targeted Therapy ; Neoplasms - genetics ; Neoplasms - therapy ; Oncology ; Patient outcomes ; Signal transduction ; Signal Transduction - genetics ; Toxicity ; Translation ; Tumors
Is Part Of: Nature reviews. Clinical oncology, 2020-07, Vol.17 (7), p.395-417
Description: For over three decades, a mainstay and goal of clinical oncology has been the development of therapies promoting the effective elimination of cancer cells by apoptosis. This programmed cell death process is mediated by several signalling pathways (referred to as intrinsic and extrinsic) triggered by multiple factors, including cellular stress, DNA damage and immune surveillance. The interaction of apoptosis pathways with other signalling mechanisms can also affect cell death. The clinical translation of effective pro-apoptotic agents involves drug discovery studies (addressing the bioavailability, stability, tumour penetration, toxicity profile in non-malignant tissues, drug interactions and off-target effects) as well as an understanding of tumour biology (including heterogeneity and evolution of resistant clones). While tumour cell death can result in response to therapy, the selection, growth and dissemination of resistant cells can ultimately be fatal. In this Review, we present the main apoptosis pathways and other signalling pathways that interact with them, and discuss actionable molecular targets, therapeutic agents in clinical translation and known mechanisms of resistance to these agents.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1759-4774
EISSN: 1759-4782
DOI: 10.1038/s41571-020-0341-y
PMID: 32203277
Source: MEDLINE
ProQuest Central

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Targeting apoptosis in cancer therapy

COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;ISSN: 1759-4774 ;EISSN: 1759-4782 ;DOI: 10.1038/s41571-020-0341-y ;PMID: 32203277

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