Language:

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

Nature reviews. Immunology, 2021-09, Vol.21 (9), p.548-569 [Peer Reviewed Journal]

2021. Springer Nature Limited. ;COPYRIGHT 2021 Nature Publishing Group ;Springer Nature Limited 2021. ;Springer Nature Limited 2021 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/s41577-021-00524-z ;PMID: 33833439

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
The cGAS-STING pathway as a therapeutic target in inflammatory diseases
Author: Decout, Alexiane ; Katz, Jason D ; Venkatraman, Shankar ; Ablasser, Andrea
Subjects: Adaptor Proteins, Signal Transducing - antagonists & inhibitors ; Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - immunology ; Animals ; Antagonists ; Autoimmune diseases ; Autophagy ; Cell Death ; Cell Proliferation ; Cellular signal transduction ; Cellular stress response ; Cyclic adenylic acid ; Cyclic guanylic acid ; Degeneration (Pathology) ; Development and progression ; DNA, Mitochondrial - genetics ; DNA, Mitochondrial - metabolism ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - therapeutic use ; Gain of Function Mutation ; Genetic aspects ; Health aspects ; Humans ; Immune response ; Inflammation ; Inflammation - immunology ; Inflammation - metabolism ; Inflammation - therapy ; Inflammation Mediators - antagonists & inhibitors ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; Inflammatory diseases ; Membrane Proteins - antagonists & inhibitors ; Membrane Proteins - genetics ; Membrane Proteins - immunology ; Models, Biological ; Models, Molecular ; Nucleotides, Cyclic - immunology ; Nucleotides, Cyclic - metabolism ; Nucleotidyltransferases - antagonists & inhibitors ; Nucleotidyltransferases - genetics ; Nucleotidyltransferases - immunology ; Review ; Signal transduction ; Signal Transduction - drug effects ; Signal Transduction - genetics ; Signal Transduction - immunology
Is Part Of: Nature reviews. Immunology, 2021-09, Vol.21 (9), p.548-569
Description: The cGAS-STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS-STING pathway is its capacity to sense and regulate the cellular response towards microbial and host-derived DNAs, which serve as ubiquitous danger-associated molecules. Insights into the structural and molecular biology of the cGAS-STING pathway have enabled the development of selective small-molecule inhibitors with the potential to target the cGAS-STING axis in a number of inflammatory diseases in humans. Here, we outline the principal elements of the cGAS-STING signalling cascade and discuss the general mechanisms underlying the association of cGAS-STING activity with various autoinflammatory, autoimmune and degenerative diseases. Finally, we outline the chemical nature of recently developed cGAS and STING antagonists and summarize their potential clinical applications.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1733
EISSN: 1474-1741
DOI: 10.1038/s41577-021-00524-z
PMID: 33833439
Source: MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

2021. Springer Nature Limited. ;COPYRIGHT 2021 Nature Publishing Group ;Springer Nature Limited 2021. ;Springer Nature Limited 2021 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/s41577-021-00524-z ;PMID: 33833439

Searching Remote Databases, Please Wait