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Exosomes from adipose‐derived stem cells and application to skin wound healing

Cell proliferation, 2021-03, Vol.54 (3), p.e12993-n/a [Peer Reviewed Journal]

2021 The Authors. Published by John Wiley & Sons Ltd. ;2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd. ;2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0960-7722 ;EISSN: 1365-2184 ;DOI: 10.1111/cpr.12993 ;PMID: 33458899

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Title:
Exosomes from adipose‐derived stem cells and application to skin wound healing
Author: An, Yang ; Lin, Shuyan ; Tan, Xiaojie ; Zhu, Shiou ; Nie, Fangfei ; Zhen, Yonghuan ; Gu, Luosha ; Zhang, Chunlei ; Wang, Baicheng ; Wei, Wei ; Li, Dong ; Wu, Junhao
Subjects: Adipocytes - cytology ; adipose‐derived stem cells ; Angiogenesis ; Animals ; Biosynthesis ; Body fat ; Cell proliferation ; Collagen ; Cytokines ; Diabetes ; Diabetes mellitus ; Dosage ; Exosomes ; Exosomes - metabolism ; Exosomes - transplantation ; Extracellular matrix ; Growth factors ; Heat shock proteins ; Humans ; Hyperplasia ; Immune response ; Immune system ; Immunoglobulins ; inflammation ; Membranes ; Mesenchymal Stem Cells - cytology ; Microscopy ; Plasma ; Review ; Reviews ; Skin ; Skin - cytology ; skin wound healing ; Stem cells ; Stem Cells - cytology ; Trauma ; Wound healing ; Wound Healing - physiology
Is Part Of: Cell proliferation, 2021-03, Vol.54 (3), p.e12993-n/a
Description: Skin wound healing is an intractable problem that represents an urgent clinical need. To solve this problem, a large number of studies have focused on the use of exosomes (EXOs) derived from adipose‐derived stem cells (ADSCs). This review describes the mechanisms whereby ADSCs‐EXOs regulate wound healing and their clinical application. In the wound, ADSCs‐EXOs modulate immune responses and inflammation. They also promote angiogenesis, accelerate proliferation and re‐epithelization of skin cells, and regulate collagen remodelling which inhibits scar hyperplasia. Compared with ADSCs therapeutics, ADSCs‐EXOs have highly stability and are easily stored. Additionally, they are not rejected by the immune system and have a homing effect and their dosage can be easily controlled. ADSCs‐EXOs can improve fat grafting and promote wound healing in patients with diabetes mellitus. They can also act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair. Overall, ADSCs‐EXOs have the potential to be used in the clinic to promote wound healing. This review describes the mechanisms whereby exosomes (EXOs) derived from adipose‐derived stem cells (ADSCs) regulate wound healing and their clinical application. In the wound, ADSCs‐EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re‐epithelization of skin cells and regulate collagen remodelling, which inhibits scar hyperplasia. ADSCs‐EXOs have the potential to be used in the clinic, as they can improve fat grafting, promote wound healing of diabetic patients and act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair.
Publisher: England: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 0960-7722
EISSN: 1365-2184
DOI: 10.1111/cpr.12993
PMID: 33458899
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Exosomes from adipose‐derived stem cells and application to skin wound healing

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