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The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants

The EMBO journal, 2021-01, Vol.40 (2), p.e104559-n/a [Peer Reviewed Journal]

2020 The Authors ;2020 The Authors. ;2021 EMBO ;ISSN: 0261-4189 ;EISSN: 1460-2075 ;DOI: 10.15252/embj.2020104559 ;PMID: 33372703

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Title:
The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants
Author: Liu, Qiangbo ; Ding, Yanglin ; Shi, Yiting ; Ma, Liang ; Wang, Yi ; Song, Chunpeng ; Wilkins, Katie A ; Davies, Julia M ; Knight, Heather ; Knight, Marc R ; Gong, Zhizhong ; Guo, Yan ; Yang, Shuhua
Subjects: Arabidopsis ; Arabidopsis - metabolism ; Arabidopsis Proteins - metabolism ; Calcium ; Calcium - metabolism ; Calcium influx ; Calcium ions ; Calcium permeability ; calcium signal ; Calcium Signaling - physiology ; Calcium signalling ; Calcium transport ; calcium‐permeable transporter AtANN1 ; Cell Membrane - metabolism ; Cold ; Cold Temperature ; Cold tolerance ; Cold-Shock Response - physiology ; Cytosol ; Freezing ; freezing tolerance ; Gene Expression Regulation, Plant - physiology ; Genes ; Genetic analysis ; Kinases ; Mutants ; OST1 kinase ; Plant cells ; Protein Kinases - metabolism ; Signal generation ; Signaling ; Stress ; Transcription Factors - metabolism
Is Part Of: The EMBO journal, 2021-01, Vol.40 (2), p.e104559-n/a
Description: The transient elevation of cytosolic free calcium concentration ([Ca2+]cyt) induced by cold stress is a well‐established phenomenon; however, the underlying mechanism remains elusive. Here, we report that the Ca2+‐permeable transporter ANNEXIN1 (AtANN1) mediates cold‐triggered Ca2+ influx and freezing tolerance in Arabidopsis thaliana. The loss of function of AtANN1 substantially impaired freezing tolerance, reducing the cold‐induced [Ca2+]cyt increase and upregulation of the cold‐responsive CBF and COR genes. Further analysis showed that the OST1/SnRK2.6 kinase interacted with and phosphorylated AtANN1, which consequently enhanced its Ca2+ transport activity, thereby potentiating Ca2+ signaling. Consistent with these results and freezing sensitivity of ost1 mutants, the cold‐induced [Ca2+]cyt elevation in the ost1‐3 mutant was reduced. Genetic analysis indicated that AtANN1 acts downstream of OST1 in responses to cold stress. Our data thus uncover a cascade linking OST1‐AtANN1 to cold‐induced Ca2+ signal generation, which activates the cold response and consequently enhances freezing tolerance in Arabidopsis. Synopsis How cold stress generates and controls transient elevation of calcium in the cytosol of plant cells is ill‐defined. Cold‐activated OST1 kinase promotes freezing tolerance in Arabidopsis by potentiating ANNEXIN1‐dependent calcium signaling. ANNEXIN1 (AtANN1) mediates the generation of cold‐triggered Ca2+ signals. Cold‐activated OST1 kinase phosphorylates AtANN1 to enhance its Ca2+ transport activity, thereby amplifying Ca2+ signaling. OST1‐AtANN1 module regulates the expression of cold responsive CBF and COR genes and plant freezing tolerance. Cold‐activated OST1 kinase phosphorylates ANNEXIN1 to boost calcium ion uptake and thus promotes expression of COR genes that enhance cold stress responses in Arabidopsis.
Publisher: England: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0261-4189
EISSN: 1460-2075
DOI: 10.15252/embj.2020104559
PMID: 33372703
Source: Geneva Foundation Free Medical Journals at publisher websites
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PubMed Central
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The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants

2020 The Authors ;2020 The Authors. ;2021 EMBO ;ISSN: 0261-4189 ;EISSN: 1460-2075 ;DOI: 10.15252/embj.2020104559 ;PMID: 33372703

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