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Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit

Neuron (Cambridge, Mass.), 2020-05, Vol.106 (4), p.637-648.e6 [Peer Reviewed Journal]

2020 Elsevier Inc. ;Copyright © 2020 Elsevier Inc. All rights reserved. ;2020. Elsevier Inc. ;ISSN: 0896-6273 ;EISSN: 1097-4199 ;DOI: 10.1016/j.neuron.2020.02.014 ;PMID: 32164875

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Title:
Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit
Author: Falkner, Annegret L. ; Wei, Dongyu ; Song, Anjeli ; Watsek, Li W. ; Chen, Irene ; Chen, Patricia ; Feng, James E. ; Lin, Dayu
Subjects: Aggression ; Aggression - physiology ; Aggressiveness ; Animals ; Behavior ; Biting ; Brain ; circuit ; Female ; Gene expression ; Hypothalamus ; Hypothalamus (ventromedial) ; Jaw ; jaw muscle ; Latency ; Male ; Males ; Mesencephalon ; Mesencephalon - cytology ; Mesencephalon - physiology ; Mice ; Muscles ; Neural Pathways - cytology ; Neural Pathways - physiology ; Neurons ; Neurons - cytology ; Neurons - physiology ; periaqueductal gray ; social behavior ; Social interactions ; Ventromedial Hypothalamic Nucleus - cytology ; Ventromedial Hypothalamic Nucleus - physiology
Is Part Of: Neuron (Cambridge, Mass.), 2020-05, Vol.106 (4), p.637-648.e6
Description: Although the ventromedial hypothalamus ventrolateral area (VMHvl) is now well established as a critical locus for the generation of conspecific aggression, its role is complex, with neurons responding during multiple phases of social interactions with both males and females. It has been previously unclear how the brain uses this complex multidimensional signal and coordinates a discrete action: the attack. Here, we find a hypothalamic-midbrain circuit that represents hierarchically organized social signals during aggression. Optogenetic-assisted circuit mapping reveals a preferential projection from VMHvlvGlut2 to lPAGvGlut2 cells, and inactivation of downstream lPAGvGlut2 populations results in aggression-specific deficits. lPAG neurons are selective for attack action and exhibit short-latency, time-locked spiking relative to the activity of jaw muscles during biting. Last, we find that this projection conveys male-biased signals from the VMHvl to downstream lPAGvGlut2 neurons that are sensitive to features of ongoing activity, suggesting that action selectivity is generated by a combination of pre- and postsynaptic mechanisms. [Display omitted] •VMHvlvGlut2 neurons target lPAGvGlut2 neurons that project polysynaptically to the jaw•Inactivating lPAGvGlut2 neurons results in aggressive action-specific deficits•Single-unit lPAG activity is action specific and time locked to EMG-detected biting•VMHvl-lPAG projection relays male-biased signals to generate action selectivity Although stimulation of the hypothalamus has long been known to evoke attack, how these neurons organize aggressive action is unknown. Here, Falkner et al. describe an excitatory hypothalamic-midbrain circuit that transforms generalized social information into an action-specific neural code that is time locked to the bite during attack.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0896-6273
EISSN: 1097-4199
DOI: 10.1016/j.neuron.2020.02.014
PMID: 32164875
Source: Cell Press Free Archives
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Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit

2020 Elsevier Inc. ;Copyright © 2020 Elsevier Inc. All rights reserved. ;2020. Elsevier Inc. ;ISSN: 0896-6273 ;EISSN: 1097-4199 ;DOI: 10.1016/j.neuron.2020.02.014 ;PMID: 32164875

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