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Immunological considerations for COVID-19 vaccine strategies

Nature reviews. Immunology, 2020-10, Vol.20 (10), p.615-632 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;Springer Nature Limited 2020 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/s41577-020-00434-6 ;PMID: 32887954

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Title:
Immunological considerations for COVID-19 vaccine strategies
Author: Jeyanathan, Mangalakumari ; Afkhami, Sam ; Smaill, Fiona ; Miller, Matthew S ; Lichty, Brian D ; Xing, Zhou
Subjects: Analysis ; Antibodies, Viral - biosynthesis ; BCG ; BCG vaccines ; Betacoronavirus - drug effects ; Betacoronavirus - immunology ; Betacoronavirus - pathogenicity ; Clinical Trials as Topic ; Coronaviridae ; Coronavirus Infections - epidemiology ; Coronavirus Infections - immunology ; Coronavirus Infections - prevention & control ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; COVID-19 Vaccines ; Epidemics ; Genetic Vectors - chemistry ; Genetic Vectors - immunology ; Health aspects ; Humans ; Immunity, Herd - drug effects ; Immunity, Innate - drug effects ; Immunization Schedule ; Immunogenicity, Vaccine ; Immunology ; Pandemics ; Pandemics - prevention & control ; Patient Safety ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - immunology ; Pneumonia, Viral - prevention & control ; Pneumonia, Viral - virology ; Review ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe Acute Respiratory Syndrome - epidemiology ; Severe Acute Respiratory Syndrome - immunology ; Severe Acute Respiratory Syndrome - prevention & control ; Severe Acute Respiratory Syndrome - virology ; Severe acute respiratory syndrome coronavirus 2 ; Vaccination ; Vaccines ; Vaccines, Attenuated ; Vaccines, DNA ; Vaccines, Subunit ; Vaccines, Virus-Like Particle ; Viral Vaccines - administration & dosage ; Viral Vaccines - biosynthesis ; Viral Vaccines - immunology
Is Part Of: Nature reviews. Immunology, 2020-10, Vol.20 (10), p.615-632
Description: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to humanity in a century. It is widely believed that prepandemic normalcy will never return until a safe and effective vaccine strategy becomes available and a global vaccination programme is implemented successfully. Here, we discuss the immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies. On the basis of these principles, we examine the current COVID-19 vaccine candidates, their strengths and potential shortfalls, and make inferences about their chances of success. Finally, we discuss the scientific and practical challenges that will be faced in the process of developing a successful vaccine and the ways in which COVID-19 vaccine strategies may evolve over the next few years.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1733
EISSN: 1474-1741
DOI: 10.1038/s41577-020-00434-6
PMID: 32887954
Source: MEDLINE
ProQuest Central

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Immunological considerations for COVID-19 vaccine strategies

COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;Springer Nature Limited 2020 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/s41577-020-00434-6 ;PMID: 32887954

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