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A Guide to COVID‐19: a global pandemic caused by the novel coronavirus SARS‐CoV‐2

The FEBS journal, 2020-09, Vol.287 (17), p.3633-3650 [Peer Reviewed Journal]

2020 Federation of European Biochemical Societies ;2020 Federation of European Biochemical Societies. ;Copyright © 2020 Federation of European Biochemical Societies ;ISSN: 1742-464X ;EISSN: 1742-4658 ;DOI: 10.1111/febs.15375 ;PMID: 32446285

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Title:
A Guide to COVID‐19: a global pandemic caused by the novel coronavirus SARS‐CoV‐2
Author: Atzrodt, Cassandra L. ; Maknojia, Insha ; McCarthy, Robert D. P. ; Oldfield, Tiara M. ; Po, Jonathan ; Ta, Kenny T. L. ; Stepp, Hannah E. ; Clements, Thomas P.
Subjects: A Guide To ; ACE2 ; Adenosine Monophosphate - analogs & derivatives ; Adenosine Monophosphate - therapeutic use ; Alanine - analogs & derivatives ; Alanine - therapeutic use ; Antiviral Agents - therapeutic use ; Coronaviridae ; coronavirus ; Coronavirus Infections - drug therapy ; Coronavirus Infections - epidemiology ; Coronavirus Infections - immunology ; Coronavirus Infections - pathology ; Coronaviruses ; COVID-19 ; COVID-19 - drug therapy ; COVID-19 - epidemiology ; COVID-19 - immunology ; COVID-19 - pathology ; COVID-19 Testing - methods ; COVID-19 Vaccines - therapeutic use ; CRISPR ; Disease transmission ; Drug Combinations ; Drugs ; Epidemiology ; Fever ; Humans ; Hydroxychloroquine - therapeutic use ; Inhalation ; Interferon beta-1a - therapeutic use ; Lopinavir - therapeutic use ; MERS ; MERS‐CoV ; Middle East Respiratory Syndrome Coronavirus - immunology ; Middle East Respiratory Syndrome Coronavirus - pathogenicity ; Pandemics ; Prophylaxis ; Respiration ; Respiration, Artificial - methods ; Ritonavir - therapeutic use ; SARS ; SARS Virus - immunology ; SARS Virus - pathogenicity ; SARS-CoV-2 - drug effects ; SARS-CoV-2 - immunology ; SARS-CoV-2 - pathogenicity ; SARS‐CoV ; SARS‐CoV‐2 ; Severe acute respiratory syndrome ; Severe Acute Respiratory Syndrome - drug therapy ; Severe Acute Respiratory Syndrome - epidemiology ; Severe Acute Respiratory Syndrome - immunology ; Severe Acute Respiratory Syndrome - pathology ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Testing procedures ; vaccine ; Vaccines ; Viral diseases ; Viruses
Is Part Of: The FEBS journal, 2020-09, Vol.287 (17), p.3633-3650
Description: The emergence of the SARS‐CoV‐2 strain of the human coronavirus has thrown the world into the midst of a new pandemic. In the human body, the virus causes COVID‐19, a disease characterized by shortness of breath, fever, and pneumonia, which can be fatal in vulnerable individuals. SARS‐CoV‐2 has characteristics of past human coronaviruses, with close genomic similarities to SARS‐CoV, the virus that causes the disease SARS. Like these related coronaviruses, SARS‐CoV‐2 is transmitted through the inhalation of droplets and interaction with contaminated surfaces. Across the world, laboratories are developing candidate vaccines for the virus – with vaccine trials underway in the United States and the United Kingdom – and considering various drugs for possible treatments and prophylaxis. Here, we provide an overview of SARS‐CoV‐2 by analyzing its virology, epidemiology, and modes of transmission while examining the current progress of testing procedures and possible treatments through drugs and vaccines. This review was written for the purpose of educating the public about the scientific aspects of SARS‐CoV‐2 that may be difficult to gather in the media. This review contains background information of SARS‐CoV‐2 as well as other coronaviruses. It also gives an overview of more technical topics, such as the structure of the virus and how scientists are working to create methods for testing, treatment, and further prevention of outbreaks.
Publisher: England: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 1742-464X
EISSN: 1742-4658
DOI: 10.1111/febs.15375
PMID: 32446285
Source: GFMER Free Medical Journals
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A Guide to COVID‐19: a global pandemic caused by the novel coronavirus SARS‐CoV‐2

2020 Federation of European Biochemical Societies ;2020 Federation of European Biochemical Societies. ;Copyright © 2020 Federation of European Biochemical Societies ;ISSN: 1742-464X ;EISSN: 1742-4658 ;DOI: 10.1111/febs.15375 ;PMID: 32446285

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