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mTOR at the nexus of nutrition, growth, ageing and disease

Nature reviews. Molecular cell biology, 2020-04, Vol.21 (4), p.183-203 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;2020© Springer Nature Limited 2020 ;Springer Nature Limited 2020. ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/s41580-019-0199-y ;PMID: 31937935

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Title:
mTOR at the nexus of nutrition, growth, ageing and disease
Author: Liu, Grace Y ; Sabatini, David M
Subjects: Accumulation ; Aging ; Aging - metabolism ; Animals ; Autophagy ; Autophagy - physiology ; Biomass ; Cancer ; Cellular signal transduction ; Growth factors ; Homeostasis ; Humans ; Mapping ; Metabolic Diseases - metabolism ; Metabolic disorders ; Neoplasms - metabolism ; Neurodegeneration ; Nutrition ; Nutritional status ; Nutritional Status - physiology ; Observations ; Phagocytosis ; Pharmacology ; Physiological aspects ; Protein biosynthesis ; Protein Biosynthesis - physiology ; Protein kinases ; Protein synthesis ; Proteins ; Signal transduction ; Signal Transduction - physiology ; Signaling ; TOR protein ; TOR Serine-Threonine Kinases - genetics ; TOR Serine-Threonine Kinases - metabolism
Is Part Of: Nature reviews. Molecular cell biology, 2020-04, Vol.21 (4), p.183-203
Description: The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway's central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/s41580-019-0199-y
PMID: 31937935
Source: MEDLINE
ProQuest Central

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mTOR at the nexus of nutrition, growth, ageing and disease

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;2020© Springer Nature Limited 2020 ;Springer Nature Limited 2020. ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/s41580-019-0199-y ;PMID: 31937935

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