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Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations

Journal of neuropathology and experimental neurology, 2020-03, Vol.79 (3), p.305-313 [Peer Reviewed Journal]

2019 American Association of Neuropathologists, Inc. All rights reserved. 2019 ;2020 by American Association of Neuropathologists, Inc. ;2019 American Association of Neuropathologists, Inc. All rights reserved. ;COPYRIGHT 2020 Oxford University Press ;ISSN: 0022-3069 ;EISSN: 1554-6578 ;DOI: 10.1093/jnen/nlz126 ;PMID: 31845964

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  • Title:
    Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations
  • Author: Besser, Lilah M ; Teylan, Merilee A ; Nelson, Peter T
  • Subjects: Age factors in disease ; Aged, 80 and over ; Brain - pathology ; Brain research ; Clinical pathology ; Diagnosis ; DNA binding proteins ; Encephalopathy ; Female ; Health aspects ; Humans ; Limbic System - pathology ; Male ; Neuropathology ; Original ; Risk Factors ; TDP-43 Proteinopathies - complications ; TDP-43 Proteinopathies - diagnosis ; TDP-43 Proteinopathies - pathology
  • Is Part Of: Journal of neuropathology and experimental neurology, 2020-03, Vol.79 (3), p.305-313
  • Description: Abstract Recently, a consensus working group provided new terminology for a common disease entity, limbic predominant age-related TDP-43 encephalopathy (LATE), and its neuropathological substrate (LATE-NC). LATE-NC not only often co-occurs with Alzheimer disease neuropathological change (ADNC), but also may present in isolation. The present study aimed to investigate potential risk factors and neuropathological characteristics associated with LATE-NC. A sample of 616 autopsied participants (>75 years at death), with TDP-43 immunohistochemical studies performed, was obtained from the National Alzheimer’s Coordinating Center. Logistic regression analyses examined associations between demographic, clinical and neuropathological characteristics and LATE-NC (TDP-43 in amygdala, hippocampus, or entorhinal/inferior temporal cortex) (alpha = 0.05). Adjusted models indicated that ADNC, hippocampal sclerosis (HS), arteriolosclerosis, and limbic or amygdala-predominant Lewy body disease (LBD), but not other LBD subtypes, were associated with higher odds of LATE-NC, whereas congestive heart failure (CHF) and motor problems as first predominant symptom were associated with lower odds of LATE-NC. Our findings corroborate previous studies indicating associations between LATE-NC and ADNC, HS, and arteriolosclerosis. Novel findings suggest the association with LATE-NC is restricted to amygdala/limbic-predominant subtype of LBD, and a possible protective (or competing risk) association with CHF. This study may inform future hypothesis-driven research on LATE-NC, a common brain disease of aging.
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0022-3069
    EISSN: 1554-6578
    DOI: 10.1093/jnen/nlz126
    PMID: 31845964
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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