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Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

FEBS letters, 2018-03, Vol.592 (5), p.728-742 [Peer Reviewed Journal]

2017 Federation of European Biochemical Societies ;2017 Federation of European Biochemical Societies. ;ISSN: 0014-5793 ;EISSN: 1873-3468 ;DOI: 10.1002/1873-3468.12956 ;PMID: 29281123

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Title:
Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
Author: Nissanka, Nadee ; Moraes, Carlos T.
Subjects: Animals ; DNA Damage ; DNA, Mitochondrial - genetics ; DNA, Mitochondrial - metabolism ; Humans ; mitochondrial DNA ; neurodegeneration ; Neurodegenerative Diseases - genetics ; Neurodegenerative Diseases - metabolism ; Neurodegenerative Diseases - pathology ; Oxidative Phosphorylation ; reactive oxygen species ; Reactive Oxygen Species - metabolism
Is Part Of: FEBS letters, 2018-03, Vol.592 (5), p.728-742
Description: Mitochondria are essential organelles within the cell where most ATP is produced through oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are encoded by the mitochondrial DNA (mtDNA). One consequence of OXPHOS is the production of mitochondrial reactive oxygen species (ROS), whose role in mediating cellular damage, particularly in damaging mtDNA during ageing, has been controversial. There are subsets of neurons that appear to be more sensitive to ROS‐induced damage, and mitochondrial dysfunction has been associated with several neurodegenerative disorders. In this review, we will discuss the current knowledge in the field of mtDNA and neurodegeneration, the debate about ROS as a pathological or beneficial contributor to neuronal function, bona fide mtDNA diseases, and insights from mouse models of mtDNA defects affecting the central nervous system.
Publisher: England
Language: English
Identifier: ISSN: 0014-5793
EISSN: 1873-3468
DOI: 10.1002/1873-3468.12956
PMID: 29281123
Source: GFMER Free Medical Journals
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Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

2017 Federation of European Biochemical Societies ;2017 Federation of European Biochemical Societies. ;ISSN: 0014-5793 ;EISSN: 1873-3468 ;DOI: 10.1002/1873-3468.12956 ;PMID: 29281123

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