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Aversive Training Induces Both Presynaptic and Postsynaptic Suppression in Drosophila

The Journal of neuroscience, 2019-11, Vol.39 (46), p.9164-9172 [Peer Reviewed Journal]

Copyright © 2019 the authors. ;Copyright Society for Neuroscience Nov 13, 2019 ;Copyright © 2019 the authors 2019 ;ISSN: 0270-6474 ;EISSN: 1529-2401 ;DOI: 10.1523/JNEUROSCI.1420-19.2019 ;PMID: 31558620

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  • Title:
    Aversive Training Induces Both Presynaptic and Postsynaptic Suppression in Drosophila
  • Author: Zhang, Xiaofan ; Noyes, Nathaniel C ; Zeng, Jianzhi ; Li, Yulong ; Davis, Ronald L
  • Subjects: Acetylcholine ; Activation ; Approach behavior ; Avoidance behavior ; Calcium ; Circuits ; Conditioning ; Dendrites ; Drosophila ; In vivo methods and tests ; Insects ; Neurons ; Odor ; Odors ; Olfactory discrimination learning ; Receptor mechanisms ; γ-Aminobutyric acid A receptors
  • Is Part Of: The Journal of neuroscience, 2019-11, Vol.39 (46), p.9164-9172
  • Description: The α'β' subtype of mushroom body neurons (MBn) is required for memory acquisition, consolidation and early memory retrieval after aversive olfactory conditioning. However, functional imaging studies have failed to detect an early forming memory trace in these neurons as reflected by an enhanced G-CaMP signal in response to presentation of the learned odor. Moreover, whether cellular memory traces form early after conditioning in the mushroom body output neurons (MBOn) downstream of the α'β' MBn remains unknown. Here, we show that aversive olfactory conditioning suppresses the calcium responses to the learned odor in both α'3 and α'2 axon segments of α'β' MBn and in the dendrites of α'3 MBOn immediately after conditioning using female flies. Notably, the cellular memory traces in both α'3 MBn and α'3 MBOn are short-lived and persist for <30 min. The suppressed response in α'3 MBn is accompanied by a reduction of acetylcholine (ACh) release, suggesting that the memory trace in postsynaptic α'3 MBOn may simply reflect the suppression in presynaptic α'3 MBn. Furthermore, we show that the α'3 MBn memory trace does not occur from the inhibition of GABAergic neurons via GABA receptor activation. Because activation of the α'3 MBOn drives approach behavior of adult flies, our results demonstrate that aversive conditioning promotes avoidance behavior through suppression of the α'3 MBn-MBOn circuit. learn to avoid an odor if that odor is repeatedly paired with electric shock. Mushroom body neurons (MBns) are known to be major cell types that mediate this form of aversive conditioning. Here we show that aversive conditioning causes a reduced response to the conditioned odor in an axon branch of one subtype of the MBn for no more than 30 min after conditioning, and in the dendrites of postsynaptic, MB output neurons (MBOns). Because experimenter-induced activation of the MBOn induces approach behavior by the fly, our data support a model that aversive learning promotes avoidance by suppressing the MBn-MBOn synapses that normally promote attraction.
  • Publisher: United States: Society for Neuroscience
  • Language: English
  • Identifier: ISSN: 0270-6474
    EISSN: 1529-2401
    DOI: 10.1523/JNEUROSCI.1420-19.2019
    PMID: 31558620
  • Source: GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
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