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Alteration in tumoural PD-L1 expression and stromal CD8-positive tumour-infiltrating lymphocytes after concurrent chemo-radiotherapy for non-small cell lung cancer

British journal of cancer, 2019-09, Vol.121 (6), p.490-496 [Peer Reviewed Journal]

Copyright Nature Publishing Group Sep 2019 ;The Author(s), under exclusive licence to Cancer Research UK 2019 ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/s41416-019-0541-3 ;PMID: 31388183

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Title:
Alteration in tumoural PD-L1 expression and stromal CD8-positive tumour-infiltrating lymphocytes after concurrent chemo-radiotherapy for non-small cell lung cancer
Author: Yoneda, Kazue ; Kuwata, Taiji ; Kanayama, Masatoshi ; Mori, Masataka ; Kawanami, Toshinori ; Yatera, Kazuhiro ; Ohguri, Takayuki ; Hisaoka, Masanori ; Nakayama, Toshiyuki ; Tanaka, Fumihiro
Subjects: Adenocarcinoma of Lung - immunology ; Adenocarcinoma of Lung - metabolism ; Adenocarcinoma of Lung - pathology ; Adenocarcinoma of Lung - therapy ; Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen - metabolism ; Biomarkers, Tumor - analysis ; Carcinoma, Non-Small-Cell Lung - immunology ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - therapy ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Chemoradiotherapy - mortality ; Chemotherapy ; Density ; Drug therapy ; Female ; Follow-Up Studies ; Humans ; Lung cancer ; Lung Neoplasms - immunology ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Lung Neoplasms - therapy ; Lymphocytes ; Lymphocytes, Tumor-Infiltrating - immunology ; Medical prognosis ; Middle Aged ; Monoclonal antibodies ; Neoplasm Recurrence, Local - immunology ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - therapy ; Non-small cell lung carcinoma ; PD-L1 protein ; Prognosis ; Radiation therapy ; Retrospective Studies ; Survival Rate ; Targeted cancer therapy ; Tumors
Is Part Of: British journal of cancer, 2019-09, Vol.121 (6), p.490-496
Description: Consolidation treatment with an anti-PD-L1 antibody, durvalumab, following concurrent chemo-radiotherapy (cCRT) has become a new standard of care for locally advanced non-small cell lung cancer (NSCLC). The rationale of PD-L1 blockade after cCRT is based on preclinical evidence suggesting that chemotherapy and radiotherapy up-regulate tumoural PD-L1 expression, which has not been shown in clinical studies. To examine alteration in tumoural PD-L1 expression (tumour proportion score, TPS) and density of stromal CD8-positive tumour-infiltrating lymphocytes (CD8 + TILs) after cCRT, paired NSCLC samples obtained before and after cCRT were reviewed in comparison with those obtained before and after drug therapy. PD-L1 expression was significantly up-regulated after cCRT (median TPS, 1.0 at baseline versus 48.0 after cCRT; P < 0.001), but not after drug therapy. There was no significant correlation between baseline TPS and post-cCRT TPS. CD8 + TIL density was significantly increased after cCRT (median, 10.6 versus 39.1; P < 0.001), and higher post-cCRT CD8 + TIL density was associated with a higher pathologic response and with a favourable survival (P = 0.019). Tumoural PD-L1 expression was up-regulated after cCRT, which provides pathologic rationale for PD-L1 blockade following cCRT to improve prognosis. Stromal CD8 + TIL density was also increased after cCRT, and higher post-cCRT CD8 + TIL density was a favourable prognostic indicator.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0007-0920
EISSN: 1532-1827
DOI: 10.1038/s41416-019-0541-3
PMID: 31388183
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central

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Alteration in tumoural PD-L1 expression and stromal CD8-positive tumour-infiltrating lymphocytes after concurrent chemo-radiotherapy for non-small cell lung cancer

Copyright Nature Publishing Group Sep 2019 ;The Author(s), under exclusive licence to Cancer Research UK 2019 ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/s41416-019-0541-3 ;PMID: 31388183

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