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Distinct fibroblast subsets drive inflammation and damage in arthritis

Nature (London), 2019-06, Vol.570 (7760), p.246-251 [Peer Reviewed Journal]

COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Jun 13, 2019 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-019-1263-7 ;PMID: 31142839

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Title:
Distinct fibroblast subsets drive inflammation and damage in arthritis
Author: Croft, Adam P ; Campos, Joana ; Jansen, Kathrin ; Turner, Jason D ; Marshall, Jennifer ; Attar, Moustafa ; Savary, Loriane ; Wehmeyer, Corinna ; Naylor, Amy J ; Kemble, Samuel ; Begum, Jenefa ; Dürholz, Kerstin ; Perlman, Harris ; Barone, Francesca ; McGettrick, Helen M ; Fearon, Douglas T ; Wei, Kevin ; Raychaudhuri, Soumya ; Korsunsky, Ilya ; Brenner, Michael B ; Coles, Mark ; Sansom, Stephen N ; Filer, Andrew ; Buckley, Christopher D
Subjects: Analysis ; Animal models ; Animals ; Arthritis ; Arthritis, Rheumatoid - pathology ; Bioinformatics ; Biology ; Bone and Bones - pathology ; Cartilage ; Clonal deletion ; Damage detection ; Diagnosis ; DNA damage ; Endopeptidases ; Female ; Fibroblast activation protein ; Fibroblasts ; Fibroblasts - classification ; Fibroblasts - metabolism ; Fibroblasts - pathology ; Gelatinases - metabolism ; Gene expression ; Humans ; Inflammation ; Inflammation - pathology ; Inflammatory diseases ; Joints - pathology ; Lymphocytes ; Male ; Membrane Proteins - metabolism ; Mice ; Pathogenesis ; Rheumatoid arthritis ; RNA-Seq ; Serine Endopeptidases - metabolism ; Single-Cell Analysis ; Synovial Membrane - pathology ; Thy-1 Antigens - metabolism ; Tissues ; Transcription
Is Part Of: Nature (London), 2019-06, Vol.570 (7760), p.246-251
Description: The identification of lymphocyte subsets with non-overlapping effector functions has been pivotal to the development of targeted therapies in immune-mediated inflammatory diseases (IMIDs) . However, it remains unclear whether fibroblast subclasses with non-overlapping functions also exist and are responsible for the wide variety of tissue-driven processes observed in IMIDs, such as inflammation and damage . Here we identify and describe the biology of distinct subsets of fibroblasts responsible for mediating either inflammation or tissue damage in arthritis. We show that deletion of fibroblast activation protein-α (FAPα) fibroblasts suppressed both inflammation and bone erosions in mouse models of resolving and persistent arthritis. Single-cell transcriptional analysis identified two distinct fibroblast subsets within the FAPα population: FAPα THY1 immune effector fibroblasts located in the synovial sub-lining, and FAPα THY1 destructive fibroblasts restricted to the synovial lining layer. When adoptively transferred into the joint, FAPα THY1 fibroblasts selectively mediate bone and cartilage damage with little effect on inflammation, whereas transfer of FAPα THY1 fibroblasts resulted in a more severe and persistent inflammatory arthritis, with minimal effect on bone and cartilage. Our findings describing anatomically discrete, functionally distinct fibroblast subsets with non-overlapping functions have important implications for cell-based therapies aimed at modulating inflammation and tissue damage.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/s41586-019-1263-7
PMID: 31142839
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Distinct fibroblast subsets drive inflammation and damage in arthritis

COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Jun 13, 2019 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-019-1263-7 ;PMID: 31142839

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