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Integrin trafficking in cells and tissues

Nature cell biology, 2019-02, Vol.21 (2), p.122-132 [Peer Reviewed Journal]

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Title:
Integrin trafficking in cells and tissues
Author: Moreno-Layseca, Paulina ; Icha, Jaroslav ; Hamidi, Hellyeh ; Ivaska, Johanna
Subjects: Animals ; Cell Adhesion ; Cell adhesion & migration ; Cell Membrane - metabolism ; Cell membranes ; Cell Movement ; Cell research ; Cell surface ; Cytological research ; Endocytosis ; Extracellular matrix ; Humans ; Integrins ; Integrins - metabolism ; Membrane trafficking ; Models, Biological ; Physiological aspects ; Protein Transport ; Proteins ; Receptors ; Signal Transduction
Is Part Of: Nature cell biology, 2019-02, Vol.21 (2), p.122-132
Description: Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1465-7392
EISSN: 1476-4679
DOI: 10.1038/s41556-018-0223-z
PMID: 30602723
Source: MEDLINE
ProQuest Central

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