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Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering

Tissue engineering. Part A, 2019-05, Vol.25 (9-10), p.679-687 [Peer Reviewed Journal]

2019, Mary Ann Liebert, Inc., publishers ;Copyright 2019, Mary Ann Liebert, Inc., publishers 2019 ;ISSN: 1937-3341 ;EISSN: 1937-335X ;DOI: 10.1089/ten.tea.2019.0032 ;PMID: 30727841

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  • Title:
    Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering
  • Author: Hoffman, Tyler ; Khademhosseini, Ali ; Langer, Robert
  • Subjects: Bioprinting - history ; History, 20th Century ; History, 21st Century ; Humans ; Perspectives—25th Anniversary of Tissue Engineering ; Printing, Three-Dimensional - history ; Regenerative Medicine - history ; s—25th Anniversary of Tissue Engineering ; Tissue Engineering - history ; Tissue Scaffolds
  • Is Part Of: Tissue engineering. Part A, 2019-05, Vol.25 (9-10), p.679-687
  • Description: In the past 25 years, the tissue engineering field has made incredible strides in developing tangible therapies for patients in need. Applications of the tissue engineering paradigm, involving varying configurations of cells, materials, and biochemical factors, have been explored for their regenerative capacity of virtually all tissue types. The impact and learning opportunities of current tissue engineering that inspired clinical successes are summarized. In addition, challenges associated with the translation and scale-up of therapies and replacements for complex organs, such as the heart and liver, are addressed. Platforms of research thrusts, specifically cell source, materials, fabrication, scalability, and Food and Drug Administration regulatory changes, and their respective innovations are identified for their potential to address these problems. Ideally, through their progress, tissue engineering strategies can be used to create a diverse range of easily accessible patient-specific treatments that more effectively improve quality of life.
  • Publisher: United States: Mary Ann Liebert, Inc., publishers
  • Language: English
  • Identifier: ISSN: 1937-3341
    EISSN: 1937-335X
    DOI: 10.1089/ten.tea.2019.0032
    PMID: 30727841
  • Source: MEDLINE
    Alma/SFX Local Collection
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