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Shape-, size- and structure-controlled synthesis and biocompatibility of iron oxide nanoparticles for magnetic theranostics

Theranostics, 2018-01, Vol.8 (12), p.3284-3307 [Peer Reviewed Journal]

Ivyspring International Publisher 2018 ;ISSN: 1838-7640 ;EISSN: 1838-7640 ;DOI: 10.7150/thno.25220 ;PMID: 29930730

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  • Title:
    Shape-, size- and structure-controlled synthesis and biocompatibility of iron oxide nanoparticles for magnetic theranostics
  • Author: Xie, Wensheng ; Guo, Zhenhu ; Gao, Fei ; Gao, Qin ; Wang, Dan ; Liaw, Bor-Shuang ; Cai, Qiang ; Sun, Xiaodan ; Wang, Xiumei ; Zhao, Lingyun
  • Subjects: Chemical Phenomena ; Ferric Compounds ; Humans ; Magnetics - methods ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Neoplasms - diagnosis ; Review ; Theranostic Nanomedicine - methods
  • Is Part Of: Theranostics, 2018-01, Vol.8 (12), p.3284-3307
  • Description: In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic applications of IONPs, with a special focus on cancer treatment. Firstly, we provide an overview of the controlling synthesis strategies for fabricating zero-, one- and three-dimensional IONPs with different shapes, sizes and structures. Then, the and biocompatibility evaluation and biotranslocation of IONPs are discussed in relation to their chemo-physical properties including particle size, surface properties, shape and structure. Finally, we also highlight significant achievements in magnetic theranostic applications including magnetic resonance imaging (MRI), magnetic hyperthermia and targeted drug delivery. This review provides a background on the controlled synthesis, biocompatibility evaluation and applications of IONPs as cancer theranostic agents and an overview of the most up-to-date developments in this area.
  • Publisher: Australia: Ivyspring International Publisher
  • Language: English
  • Identifier: ISSN: 1838-7640
    EISSN: 1838-7640
    DOI: 10.7150/thno.25220
    PMID: 29930730
  • Source: MEDLINE
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
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