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Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

Cell stem cell, 2018-03, Vol.22 (3), p.310-324 [Peer Reviewed Journal]

2018 Elsevier Inc. ;Copyright © 2018 Elsevier Inc. All rights reserved. ;ISSN: 1934-5909 ;EISSN: 1875-9777 ;DOI: 10.1016/j.stem.2018.02.011 ;PMID: 29499151

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Title:
Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development
Author: Ronaldson-Bouchard, Kacey ; Vunjak-Novakovic, Gordana
Subjects: Animals ; Blood-Brain Barrier - physiology ; disease modeling ; Drug Development ; human physiology ; human stem cells ; Humans ; Lab-On-A-Chip Devices ; microfluidics ; Neoplasms - pathology ; Organ Specificity ; precision medicine ; preclinical studies ; tissue engineering ; Tissue Engineering - methods
Is Part Of: Cell stem cell, 2018-03, Vol.22 (3), p.310-324
Description: Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable modeling of human physiology and disease. The technology has emerged from converging advances in tissue engineering, semiconductor fabrication, and human cell sourcing. Encompassing innovations in human stem cell technology, OOCs offer a promising approach to emulate human patho/physiology in vitro, and address limitations of current cell and animal models. Here, we review the design considerations for single and multi-organ OOCs, discuss remaining challenges, and highlight the potential impact of OOCs as a fast-track opportunity for tissue engineering to advance drug development and precision medicine. Ronaldson-Bouchard and Vunjak-Novakovic discuss the design considerations for single and multi-organ organs-on-a-chip (OOCs) and highlight the potential impact of OOCs as a fast-track opportunity for tissue engineering to advance drug development and precision medicine.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 1934-5909
EISSN: 1875-9777
DOI: 10.1016/j.stem.2018.02.011
PMID: 29499151
Source: Cell Press Free Archives
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Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

2018 Elsevier Inc. ;Copyright © 2018 Elsevier Inc. All rights reserved. ;ISSN: 1934-5909 ;EISSN: 1875-9777 ;DOI: 10.1016/j.stem.2018.02.011 ;PMID: 29499151

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