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Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ

Journal of clinical oncology, 2016-11, Vol.34 (33), p.4040-4046 [Peer Reviewed Journal]

2016 American Society of Clinical Oncology, Society of Surgical Oncology, and American Society for Radiation Oncology 2016 American Society of Clinical Oncology ;ISSN: 0732-183X ;EISSN: 1527-7755 ;DOI: 10.1200/JCO.2016.68.3573 ;PMID: 27528719

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Title:
Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ
Author: Morrow, Monica ; Van Zee, Kimberly J ; Solin, Lawrence J ; Houssami, Nehmat ; Chavez-MacGregor, Mariana ; Harris, Jay R ; Horton, Janet ; Hwang, Shelley ; Johnson, Peggy L ; Marinovich, M Luke ; Schnitt, Stuart J ; Wapnir, Irene ; Moran, Meena S
Subjects: ASCO Guidelines ; ASCO Special ; Breast Neoplasms - radiotherapy ; Breast Neoplasms - surgery ; Breast Neoplasms - therapy ; Carcinoma, Intraductal, Noninfiltrating - radiotherapy ; Carcinoma, Intraductal, Noninfiltrating - surgery ; Carcinoma, Intraductal, Noninfiltrating - therapy ; Consensus Development Conferences as Topic ; Female ; Humans ; Mastectomy, Segmental ; Middle Aged ; Neoplasm Recurrence, Local - prevention & control ; Societies, Medical ; Surgery ; Surgical Oncology ; United States
Is Part Of: Journal of clinical oncology, 2016-11, Vol.34 (33), p.4040-4046
Description: Background Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation (WBRT). Methods A multidisciplinary consensus panel used a meta-analysis of margin width and ipsilateral breast tumor recurrence (IBTR) from a systematic review of 20 studies including 7883 patients and other published literature as the evidence base for consensus. Results Negative margins halve the risk of IBTR compared with positive margins defined as ink on DCIS. A 2 mm margin minimizes the risk of IBTR compared with smaller negative margins. More widely clear margins do not significantly decrease IBTR compared with 2 mm margins. Negative margins less than 2 mm alone are not an indication for mastectomy, and factors known to impact rates of IBTR should be considered in determining the need for re-excision. Conclusion The use of a 2 mm margin as the standard for an adequate margin in DCIS treated with WBRT is associated with low rates of IBTR and has the potential to decrease re-excision rates, improve cosmetic outcome, and decrease health care costs. Clinical judgment should be used in determining the need for further surgery in patients with negative margins < 2 mm.
Publisher: United States: American Society of Clinical Oncology
Language: English
Identifier: ISSN: 0732-183X
EISSN: 1527-7755
DOI: 10.1200/JCO.2016.68.3573
PMID: 27528719
Source: Geneva Foundation Free Medical Journals at publisher websites
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Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ

2016 American Society of Clinical Oncology, Society of Surgical Oncology, and American Society for Radiation Oncology 2016 American Society of Clinical Oncology ;ISSN: 0732-183X ;EISSN: 1527-7755 ;DOI: 10.1200/JCO.2016.68.3573 ;PMID: 27528719

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