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A Review of Disintegration Mechanisms and Measurement Techniques

Pharmaceutical research, 2017-05, Vol.34 (5), p.890-917 [Peer Reviewed Journal]

The Author(s) 2017 ;COPYRIGHT 2017 Springer ;Pharmaceutical Research is a copyright of Springer, 2017. ;ISSN: 0724-8741 ;EISSN: 1573-904X ;DOI: 10.1007/s11095-017-2129-z ;PMID: 28251425

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Title:
A Review of Disintegration Mechanisms and Measurement Techniques
Author: Markl, Daniel ; Zeitler, J. Axel
Subjects: Analysis ; Biochemistry ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Capsules - chemistry ; Chemistry, Pharmaceutical - methods ; Dissolution ; Drug dosages ; Excipients - chemistry ; Expert Review ; Humans ; Measurement ; Medical Law ; Patient compliance ; Pharmaceuticals ; Pharmacology ; Pharmacology/Toxicology ; Pharmacy ; Powders - chemistry ; Solubility ; Tablets - chemistry ; Technology, Pharmaceutical - methods
Is Part Of: Pharmaceutical research, 2017-05, Vol.34 (5), p.890-917
Description: ABSTRACT Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically powder compacts consisting of several different excipients in addition to the API. Excipients are added to a formulation in order to achieve the desired fill weight of a dosage form, to improve the processability or to affect the drug release behaviour in the body. These complex porous systems undergo different mechanisms when they come in contact with physiological fluids. The performance of a drug is primarily influenced by the disintegration and dissolution behaviour of the powder compact. The disintegration process is specifically critical for immediate-release dosage forms. Its mechanisms and the factors impacting disintegration are discussed and methods used to study the disintegration in-situ are presented. This review further summarises mathematical models used to simulate disintegration phenomena and to predict drug release kinetics.
Publisher: New York: Springer US
Language: English
Identifier: ISSN: 0724-8741
EISSN: 1573-904X
DOI: 10.1007/s11095-017-2129-z
PMID: 28251425
Source: MEDLINE
Springer Nature OA/Free Journals
ProQuest Central

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A Review of Disintegration Mechanisms and Measurement Techniques

The Author(s) 2017 ;COPYRIGHT 2017 Springer ;Pharmaceutical Research is a copyright of Springer, 2017. ;ISSN: 0724-8741 ;EISSN: 1573-904X ;DOI: 10.1007/s11095-017-2129-z ;PMID: 28251425

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