skip to main content
Guest
My Research
My Account
Sign out
Sign in
This feature requires javascript
Library Search
Find Databases
Browse Search
E-Journals A-Z
E-Books A-Z
Citation Linker
Help
Language:
English
Vietnamese
This feature required javascript
This feature requires javascript
Primo Search
All Library Resources
All
Course Materials
Course Materials
Search For:
Clear Search Box
Search in:
All Library Resources
Or hit Enter to replace search target
Or select another collection:
Search in:
All Library Resources
Search in:
Print Resources
Search in:
Digital Resources
Search in:
Online E-Resources
Advanced Search
Browse Search
This feature requires javascript
Search Limited to:
Search Limited to:
Resource type
criteria input
All items
Books
Articles
Images
Audio Visual
Maps
Graduate theses
Show Results with:
criteria input
that contain my query words
with my exact phrase
starts with
Show Results with:
Search type Index
criteria input
anywhere in the record
in the title
as author/creator
in subject
Full Text
ISBN
ISSN
TOC
Keyword
Field
Show Results with:
in the title
Show Results with:
anywhere in the record
in the title
as author/creator
in subject
Full Text
ISBN
ISSN
TOC
Keyword
Field
This feature requires javascript
HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
Cellular & molecular immunology, 2017-01, Vol.14 (1), p.43-64
[Peer Reviewed Journal]
Copyright © 2017 The Author(s) 2017 The Author(s) ;ISSN: 1672-7681 ;EISSN: 2042-0226 ;DOI: 10.1038/cmi.2016.34 ;PMID: 27569562
Full text available
Citations
Cited by
View Online
Details
Recommendations
Reviews
Times Cited
External Links
This feature requires javascript
Actions
Add to My Research
Remove from My Research
E-mail
Print
Permalink
Citation
EasyBib
EndNote
RefWorks
Delicious
Export RIS
Export BibTeX
This feature requires javascript
Title:
HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
Author:
Bertheloot, Damien
;
Latz, Eicke
Subjects:
Alarmins - metabolism
;
Animals
;
HMGB1
;
HMGB1 Protein - metabolism
;
Humans
;
IL-1α
;
Interleukin-1alpha - metabolism
;
Interleukin-33 - metabolism
;
Models, Biological
;
Review
;
S100 Proteins - metabolism
;
S100蛋白
;
免疫系统
;
快速检测
;
生殖细胞
;
组织损伤
;
细胞死亡
Is Part Of:
Cellular & molecular immunology, 2017-01, Vol.14 (1), p.43-64
Description:
Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline- encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of endogenous molecules have been shown to provoke such sterile inflammatory states when released from dying cells. However, a group of proteins referred to as alarmins have both intracellular and extracellular functions which have been the subject of intense research. Indeed, alarmins can either exert beneficial cell housekeeping functions, leading to tissue repair, or provoke deleterious uncontrolled inflammation. This group of proteins includes the high-mobility group box 1 protein (HMGB1), interleukin (IL)-1α, IL-33 and the Ca^2+-binding S100 proteins. These dual-function proteins share conserved regulatory mechanisms, such as secretory routes, post-translational modifications and enzymatic processing, that govern their extracellular functions in time and space. Release of alarmins from mesenchymal cells is a highly relevant mechanism by which immune cells can be alerted of tissue damage, and alarmins play a key role in the development of acute or chronic inflammatory diseases and in cancer development.
Publisher:
China: Nature Publishing Group
Language:
English
Identifier:
ISSN: 1672-7681
EISSN: 2042-0226
DOI: 10.1038/cmi.2016.34
PMID: 27569562
Source:
GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central
This feature requires javascript
This feature requires javascript
Back to results list
This feature requires javascript
This feature requires javascript
Searching Remote Databases, Please Wait
Searching for
in
scope:(TDTS),scope:(SFX),scope:(TDT),scope:(SEN),primo_central_multiple_fe
Show me what you have so far
This feature requires javascript
This feature requires javascript