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Comparative genomics of biotechnologically important yeasts

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (35), p.9882-9887 [Peer Reviewed Journal]

Volumes 1–89 and 106–113, copyright as a collective work only; author(s) retains copyright to individual articles ;Copyright National Academy of Sciences Aug 30, 2016 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1603941113 ;PMID: 27535936

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Title:
Comparative genomics of biotechnologically important yeasts
Author: Riley, Robert ; Haridas, Sajeet ; Wolfe, Kenneth H. ; Lopes, Mariana R. ; Hittinger, Chris Todd ; Göker, Markus ; Salamov, Asaf A. ; Wisecaver, Jennifer H. ; Long, Tanya M. ; Calvey, Christopher H. ; Aerts, Andrea L. ; Barry, Kerrie W. ; Choi, Cindy ; Clum, Alicia ; Coughlan, Aisling Y. ; Deshpande, Shweta ; Douglass, Alexander P. ; Hanson, Sara J. ; Klenk, Hans-Peter ; LaButti, Kurt M. ; Lapidus, Alla ; Lindquist, Erika A. ; Lipzen, Anna M. ; Meier-Kolthoff, Jan P. ; Ohm, Robin A. ; Otillar, Robert P. ; Pangilinan, Jasmyn L. ; Peng, Yi ; Rokas, Antonis ; Rosa, Carlos A. ; Scheuner, Carmen ; Sibirny, Andriy A. ; Slot, Jason C. ; Stielow, J. Benjamin ; Sun, Hui ; Kurtzman, Cletus P. ; Blackwell, Meredith ; Grigoriev, Igor V. ; Jeffries, Thomas W.
Subjects: Ascomycetes ; Ascomycota - classification ; Ascomycota - genetics ; Ascomycota - metabolism ; BASIC BIOLOGICAL SCIENCES ; bioenergy ; Biological Sciences ; biotechnological yeasts ; Biotechnology ; Biotechnology - methods ; Evolution, Molecular ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; genetic code ; Genetic Code - genetics ; Genome, Fungal - genetics ; Genomics ; Genomics - methods ; Heterochromatin ; Metabolic Networks and Pathways - genetics ; microbiology ; Pachysolen tannophilus ; Phylogenetics ; Phylogeny ; Species Specificity ; Yeast ; Yeasts - classification ; Yeasts - genetics ; Yeasts - metabolism
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (35), p.9882-9887
Description: Ascomycete yeasts are metabolically diverse, with great potential for biotechnology. Here, we report the comparative genome analysis of 29 taxonomically and biotechnologically important yeasts, including 16 newly sequenced. We identify a genetic code change, CUG-Ala, in Pachysolen tannophilus in the clade sister to the known CUG-Ser clade. Our well-resolved yeast phylogeny shows that some traits, such as methylotrophy, are restricted to single clades, whereas others, such as L-rhamnose utilization, have patchy phylogenetic distributions. Gene clusters, with variable organization and distribution, encode many pathways of interest. Genomics can predict some biochemical traits precisely, but the genomic basis of others, such as xylose utilization, remains unresolved. Our data also provide insight into early evolution of ascomycetes. We document the loss of H3K9me2/3 heterochromatin, the origin of ascomycete mating-type switching, and panascomycete synteny at the MAT locus. These data and analyses will facilitate the engineering of efficient biosynthetic and degradative pathways and gateways for genomic manipulation.
Publisher: United States: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.1603941113
PMID: 27535936
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central

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Comparative genomics of biotechnologically important yeasts

Volumes 1–89 and 106–113, copyright as a collective work only; author(s) retains copyright to individual articles ;Copyright National Academy of Sciences Aug 30, 2016 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1603941113 ;PMID: 27535936

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