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The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors

The Journal of biological chemistry, 2016-04, Vol.291 (17), p.8969-8977 [Peer Reviewed Journal]

2016 © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. ;2016 by The American Society for Biochemistry and Molecular Biology, Inc. ;2016 by The American Society for Biochemistry and Molecular Biology, Inc. 2016 The American Society for Biochemistry and Molecular Biology, Inc. ;ISSN: 0021-9258 ;EISSN: 1083-351X ;DOI: 10.1074/jbc.R115.713313 ;PMID: 26984408

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Title:
The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors
Author: Smith, Jeffrey S. ; Rajagopal, Sudarshan
Subjects: 7-helix receptor ; Animals ; arrestin ; Arrestin - genetics ; Arrestin - metabolism ; G protein-coupled receptor (GPCR) ; Humans ; Minireviews ; Protein Conformation ; receptor desensitization ; receptor endocytosis ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Signal Transduction - physiology ; signaling
Is Part Of: The Journal of biological chemistry, 2016-04, Vol.291 (17), p.8969-8977
Description: The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion, βarrs adopt multiple conformations and are regulated at multiple levels to differentially activate downstream pathways. Recent structural studies have demonstrated that βarrs have a conserved structure and activation mechanism, with plasticity of their structural fold, allowing them to adopt a wide array of conformations. Novel roles for βarrs continue to be identified, demonstrating the importance of these dynamic regulators of cellular signaling.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0021-9258
EISSN: 1083-351X
DOI: 10.1074/jbc.R115.713313
PMID: 26984408
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection

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The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors

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