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Effective Modulation of Male Aggression through Lateral Septum to Medial Hypothalamus Projection

Current biology, 2016-03, Vol.26 (5), p.593-604 [Peer Reviewed Journal]

2016 Elsevier Ltd ;Copyright © 2016 Elsevier Ltd. All rights reserved. ;ISSN: 0960-9822 ;EISSN: 1879-0445 ;DOI: 10.1016/j.cub.2015.12.065 ;PMID: 26877081

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  • Title:
    Effective Modulation of Male Aggression through Lateral Septum to Medial Hypothalamus Projection
  • Author: Wong, Li Chin ; Wang, Li ; D’Amour, James A. ; Yumita, Tomohiro ; Chen, Genghe ; Yamaguchi, Takashi ; Chang, Brian C. ; Bernstein, Hannah ; You, Xuedi ; Feng, James E. ; Froemke, Robert C. ; Lin, Dayu
  • Subjects: Aggression ; Animals ; Hypothalamus, Middle - physiology ; Male ; Mice ; Mice, Inbred C57BL ; Optogenetics ; Septal Nuclei - physiology ; Sexual Behavior, Animal
  • Is Part Of: Current biology, 2016-03, Vol.26 (5), p.593-604
  • Description: Aggression is a prevalent behavior in the animal kingdom that is used to settle competition for limited resources. Given the high risk associated with fighting, the central nervous system has evolved an active mechanism to modulate its expression. Lesioning the lateral septum (LS) is known to cause “septal rage,” a phenotype characterized by a dramatic increase in the frequency of attacks. To understand the circuit mechanism of LS-mediated modulation of aggression, we examined the influence of LS input on the cells in and around the ventrolateral part of the ventromedial hypothalamus (VMHvl)—a region required for male mouse aggression. We found that the inputs from the LS inhibited the attack-excited cells but surprisingly increased the overall activity of attack-inhibited cells. Furthermore, optogenetic activation of the projection from LS cells to the VMHvl terminated ongoing attacks immediately but had little effect on mounting. Thus, LS projection to the ventromedial hypothalamic area represents an effective pathway for suppressing male aggression. [Display omitted] •Inhibiting LS increases aggression, whereas its activation suppresses ongoing attack•Activating the LS-VMHvl projection inhibits attack but not mounting behaviors•LS sends monosynaptic GABAergic inputs to the VMHvl glutamatergic cells•The LS-VMHvl pathway inhibits attack-excited cells but activates attack-inhibited cells Lesioning the lateral septum (LS) causes exaggerated aggression. Wong et al. find that LS sends direct inhibition to the ventromedial hypothalamus, ventrolateral part, a region essential for male mouse aggression. This input can effectively suppress ongoing aggression by shifting the activity balance between attack-inhibited and attack-excited cells.
  • Publisher: England: Elsevier Ltd
  • Language: English
  • Identifier: ISSN: 0960-9822
    EISSN: 1879-0445
    DOI: 10.1016/j.cub.2015.12.065
    PMID: 26877081
  • Source: Cell Press Free Archives
    MEDLINE
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