Language:

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

Brain (London, England : 1878), 2016-03, Vol.139 (Pt 3), p.807-815 [Peer Reviewed Journal]

The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. ;The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. 2016 ;ISSN: 0006-8950 ;EISSN: 1460-2156 ;DOI: 10.1093/brain/awv398 ;PMID: 26912645

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain
Author: Haider, Lukas ; Zrzavy, Tobias ; Hametner, Simon ; Höftberger, Romana ; Bagnato, Francesca ; Grabner, Günther ; Trattnig, Siegfried ; Pfeifenbring, Sabine ; Brück, Wolfgang ; Lassmann, Hans
Subjects: Brain - metabolism ; Brain - pathology ; Brain Mapping - methods ; Cerebral Cortex - metabolism ; Cerebral Cortex - pathology ; Cohort Studies ; Demyelinating Diseases - metabolism ; Demyelinating Diseases - pathology ; Humans ; Multiple Sclerosis - metabolism ; Multiple Sclerosis - pathology ; Nerve Degeneration - metabolism ; Nerve Degeneration - pathology ; Original ; White Matter - metabolism ; White Matter - pathology
Is Part Of: Brain (London, England : 1878), 2016-03, Vol.139 (Pt 3), p.807-815
Description: Multiple sclerosis is a chronic inflammatory disease with primary demyelination and neurodegeneration in the central nervous system. In our study we analysed demyelination and neurodegeneration in a large series of multiple sclerosis brains and provide a map that displays the frequency of different brain areas to be affected by these processes. Demyelination in the cerebral cortex was related to inflammatory infiltrates in the meninges, which was pronounced in invaginations of the brain surface (sulci) and possibly promoted by low flow of the cerebrospinal fluid in these areas. Focal demyelinated lesions in the white matter occurred at sites with high venous density and additionally accumulated in watershed areas of low arterial blood supply. Two different patterns of neurodegeneration in the cortex were identified: oxidative injury of cortical neurons and retrograde neurodegeneration due to axonal injury in the white matter. While oxidative injury was related to the inflammatory process in the meninges and pronounced in actively demyelinating cortical lesions, retrograde degeneration was mainly related to demyelinated lesions and axonal loss in the white matter. Our data show that accumulation of lesions and neurodegeneration in the multiple sclerosis brain does not affect all brain regions equally and provides the pathological basis for the selection of brain areas for monitoring regional injury and atrophy development in future magnetic resonance imaging studies.
Publisher: England: Oxford University Press
Language: English
Identifier: ISSN: 0006-8950
EISSN: 1460-2156
DOI: 10.1093/brain/awv398
PMID: 26912645
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. ;The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. 2016 ;ISSN: 0006-8950 ;EISSN: 1460-2156 ;DOI: 10.1093/brain/awv398 ;PMID: 26912645

Searching Remote Databases, Please Wait