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Beyond 2/3 and 1/3: The Complex Signatures of Sex-Biased Admixture on the X Chromosome

Genetics (Austin), 2015-09, Vol.201 (1), p.263-279 [Peer Reviewed Journal]

Copyright © 2015 by the Genetics Society of America. ;Copyright Genetics Society of America Sep 2015 ;Copyright © 2015 by the Genetics Society of America 2015 ;ISSN: 1943-2631 ;ISSN: 0016-6731 ;EISSN: 1943-2631 ;DOI: 10.1534/genetics.115.178509 ;PMID: 26209245 ;CODEN: GENTAE

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  • Title:
    Beyond 2/3 and 1/3: The Complex Signatures of Sex-Biased Admixture on the X Chromosome
  • Author: Goldberg, Amy ; Rosenberg, Noah A
  • Subjects: African Americans ; African Americans - genetics ; Algorithms ; Chromosomes ; Chromosomes, Human, X - genetics ; Female ; Genetics ; Human Migration ; Humans ; Investigations ; Male ; Models, Genetic ; Population Density ; Sex Factors ; Studies
  • Is Part Of: Genetics (Austin), 2015-09, Vol.201 (1), p.263-279
  • Description: Sex-biased demography, in which parameters governing migration and population size differ between females and males, has been studied through comparisons of X chromosomes, which are inherited sex-specifically, and autosomes, which are not. A common form of sex bias in humans is sex-biased admixture, in which at least one of the source populations differs in its proportions of females and males contributing to an admixed population. Studies of sex-biased admixture often examine the mean ancestry for markers on the X chromosome in relation to the autosomes. A simple framework noting that in a population with equally many females and males, two-thirds of X chromosomes appear in females, suggests that the mean X-chromosomal admixture fraction is a linear combination of female and male admixture parameters, with coefficients 2/3 and 1/3, respectively. Extending a mechanistic admixture model to accommodate the X chromosome, we demonstrate that this prediction is not generally true in admixture models, although it holds in the limit for an admixture process occurring as a single event. For a model with constant ongoing admixture, we determine the mean X-chromosomal admixture, comparing admixture on female and male X chromosomes to corresponding autosomal values. Surprisingly, in reanalyzing African-American genetic data to estimate sex-specific contributions from African and European sources, we find that the range of contributions compatible with the excess African ancestry on the X chromosome compared to autosomes has a wide spread, permitting scenarios either without male-biased contributions from Europe or without female-biased contributions from Africa.
  • Publisher: United States: Genetics Society of America
  • Language: English
  • Identifier: ISSN: 1943-2631
    ISSN: 0016-6731
    EISSN: 1943-2631
    DOI: 10.1534/genetics.115.178509
    PMID: 26209245
    CODEN: GENTAE
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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