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Disease-promoting effects of type I interferons in viral, bacterial, and coinfections

Journal of interferon & cytokine research, 2015-04, Vol.35 (4), p.252-264 [Peer Reviewed Journal]

Sophia Davidson et al. 2015; Published by Mary Ann Liebert, Inc. 2015 ;ISSN: 1079-9907 ;EISSN: 1557-7465 ;DOI: 10.1089/jir.2014.0227 ;PMID: 25714109

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  • Title:
    Disease-promoting effects of type I interferons in viral, bacterial, and coinfections
  • Author: Davidson, Sophia ; Maini, Mala K ; Wack, Andreas
  • Subjects: Bacteria ; Bacterial Infections - immunology ; Bacterial Infections - physiopathology ; Coinfection - immunology ; Coinfection - physiopathology ; Humans ; Interferon Type I - metabolism ; Reviews ; Virus Diseases - immunology ; Virus Diseases - physiopathology
  • Is Part Of: Journal of interferon & cytokine research, 2015-04, Vol.35 (4), p.252-264
  • Description: While type I interferons (IFNs) are universally acknowledged for their antiviral and immunostimulatory functions, there is increasing appreciation of the detrimental effects of inappropriate, excessive, or mistimed type I IFN responses in viral and bacterial infections. The underlying mechanisms by which type I IFNs promote susceptibility or severity include direct tissue damage by apoptosis induction or suppression of proliferation in tissue cells, immunopathology due to excessive inflammation, and cell death induced by TRAIL- and Fas-expressing immune cells, as well as immunosuppression through IL-10, IL-27, PD-L1, IL-1Ra, and other regulatory molecules that antagonize the induction or action of IL-1, IL-12, IL-17, IFN-γ, KC, and other effectors of the immune response. Bacterial superinfections following influenza infection are a prominent example of a situation where type I IFNs can misdirect the immune response. This review discusses current understanding of the parameters of signal strength, duration, timing, location, and cellular recipients that determine whether type I IFNs have beneficial or detrimental effects in infection.
  • Publisher: United States: Mary Ann Liebert, Inc
  • Language: English
  • Identifier: ISSN: 1079-9907
    EISSN: 1557-7465
    DOI: 10.1089/jir.2014.0227
    PMID: 25714109
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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