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APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease

The New England journal of medicine, 2013-12, Vol.369 (23), p.2183-2196 [Peer Reviewed Journal]

Copyright © 2013 Massachusetts Medical Society. All rights reserved. ;2014 INIST-CNRS ;Copyright © 2013 Massachusetts Medical Society. 2013 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1310345 ;PMID: 24206458 ;CODEN: NEJMAG

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Title:
APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease
Author: Parsa, Afshin ; Kao, W.H. Linda ; Xie, Dawei ; Astor, Brad C ; Li, Man ; Hsu, Chi-yuan ; Feldman, Harold I ; Parekh, Rulan S ; Kusek, John W ; Greene, Tom H ; Fink, Jeffrey C ; Anderson, Amanda H ; Choi, Michael J ; Wright, Jackson T ; Lash, James P ; Freedman, Barry I ; Ojo, Akinlolu ; Winkler, Cheryl A ; Raj, Dominic S ; Kopp, Jeffrey B ; He, Jiang ; Jensvold, Nancy G ; Tao, Kaixiang ; Lipkowitz, Michael S ; Appel, Lawrence J
Subjects: Adult ; African Americans ; African Americans - genetics ; Aged ; Apolipoprotein L1 ; Apolipoproteins ; Apolipoproteins - genetics ; Biological and medical sciences ; Creatinine ; Creatinine - blood ; Demographic aspects ; Diabetes ; Diabetes Complications - genetics ; Diabetes mellitus ; Disease Progression ; End-stage renal disease ; Epidermal growth factor receptors ; European Continental Ancestry Group - genetics ; Female ; General aspects ; Genetic aspects ; Genetic Predisposition to Disease ; Genetic variation ; Glomerular Filtration Rate ; Health aspects ; Humans ; Hypertension ; Hypertension - complications ; Kidney diseases ; Kidney Failure, Chronic - ethnology ; Kidney Failure, Chronic - genetics ; Kidneys ; Lipoproteins, HDL - genetics ; Male ; Medical sciences ; Medical treatment ; Middle Aged ; Multivariate Analysis ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Polymorphism, Single Nucleotide ; Proteinuria ; Renal failure ; Renal insufficiency ; Renal Insufficiency, Chronic - ethnology ; Renal Insufficiency, Chronic - genetics ; Risk factors ; Risk groups ; Urinary system involvement in other diseases. Miscellaneous
Is Part Of: The New England journal of medicine, 2013-12, Vol.369 (23), p.2183-2196
Description: In this study, APOL1 variants were associated with an increased risk of progression of chronic kidney disease in black patients, as compared with white patients, regardless of the cause of kidney disease or diabetes status. In the United States, black patients have approximately twice the risk of end-stage renal disease observed among white patients, after accounting for differences in socioeconomic and clinical risk factors. 1 – 4 This increased risk occurs despite a similar prevalence in earlier stages of chronic kidney disease 5 – 8 in the two racial groups, which suggests that kidney function declines more rapidly after the onset of chronic kidney disease in black patients. However, there is little direct evidence in support of this hypothesis. 9 – 13 The identification of factors that mediate differences in the progression of chronic kidney disease between black patients and white . . .
Publisher: Waltham, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1310345
PMID: 24206458
CODEN: NEJMAG
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease

Copyright © 2013 Massachusetts Medical Society. All rights reserved. ;2014 INIST-CNRS ;Copyright © 2013 Massachusetts Medical Society. 2013 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1310345 ;PMID: 24206458 ;CODEN: NEJMAG

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