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TALENs: a widely applicable technology for targeted genome editing

Nature reviews. Molecular cell biology, 2013-01, Vol.14 (1), p.49-55 [Peer Reviewed Journal]

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Title:
TALENs: a widely applicable technology for targeted genome editing
Author: Joung, J Keith ; Sander, Jeffry D
Subjects: Animals ; Deoxyribonucleases - chemistry ; Deoxyribonucleases - genetics ; Deoxyribonucleases - metabolism ; DNA - genetics ; DNA - metabolism ; DNA sequencing ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Genetic engineering ; Genetic transcription ; Genome ; Genomics ; Humans ; Nucleotide sequencing ; Protein Engineering ; Protein Structure, Tertiary ; Transcriptional Activation
Is Part Of: Nature reviews. Molecular cell biology, 2013-01, Vol.14 (1), p.49-55
Description: Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of cell types and organisms. The newly-developed transcription activator-like effector nucleases (TALENs) comprise a nonspecific DNA-cleaving nuclease fused to a DNA-binding domain that can be easily engineered so that TALENs can target essentially any sequence. The capability to quickly and efficiently alter genes using TALENs promises to have profound impacts on biological research and to yield potential therapeutic strategies for genetic diseases.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/nrm3486
PMID: 23169466
Source: MEDLINE
ProQuest Central

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