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Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

Nature reviews. Microbiology, 2011-01, Vol.9 (1), p.62-75 [Tạp chí có phản biện]

COPYRIGHT 2011 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2011 ;ISSN: 1740-1526 ;EISSN: 1740-1534 ;DOI: 10.1038/nrmicro2474 ;PMID: 21164535

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Nhan đề:
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections
Tác giả: Hurdle, Julian G ; O'Neill, Alex J ; Chopra, Ian ; Lee, Richard E
Chủ đề: Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bacteria ; Bacteria - cytology ; Bacteria - drug effects ; Bacterial infections ; Bacterial Infections - drug therapy ; Cell Membrane - drug effects ; Cell Membrane - physiology ; Cell membranes ; Drug Resistance, Bacterial ; Drug therapy ; Gene Expression Regulation, Bacterial - drug effects ; Health aspects ; Physiological aspects
Là 1 phần của: Nature reviews. Microbiology, 2011-01, Vol.9 (1), p.62-75
Mô tả: Persistent infections involving slow-growing or non-growing bacteria are hard to treat with antibiotics that target biosynthetic processes in growing cells. Consequently, there is a need for antimicrobials that can treat infections containing dormant bacteria. In this Review, we discuss the emerging concept that disrupting the bacterial membrane bilayer or proteins that are integral to membrane function (including membrane potential and energy metabolism) in dormant bacteria is a strategy for treating persistent infections. The clinical applicability of these approaches is exemplified by the efficacy of lipoglycopeptides that damage bacterial membranes and of the diarylquinoline TMC207, which inhibits membrane-bound ATP synthase. Despite some drawbacks, membrane-active agents form an important new means of eradicating recalcitrant, non-growing bacteria.
Nơi xuất bản: England: Nature Publishing Group
Ngôn ngữ: English
Số nhận dạng: ISSN: 1740-1526
EISSN: 1740-1534
DOI: 10.1038/nrmicro2474
PMID: 21164535
Nguồn: AUTh Library subscriptions: ProQuest Central
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Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

COPYRIGHT 2011 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2011 ;ISSN: 1740-1526 ;EISSN: 1740-1534 ;DOI: 10.1038/nrmicro2474 ;PMID: 21164535

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