Language:

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

Nature (London), 2012-02, Vol.482 (7383), p.85-88 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2012 Nature Publishing Group ;COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Feb 2, 2012 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature10754 ;PMID: 22258508 ;CODEN: NATUAS

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Neuron-type-specific signals for reward and punishment in the ventral tegmental area
Author: COHEN, Jeremiah Y ; HAESLER, Sebastian ; LINH VONG ; LOWELL, Bradford B ; UCHIDA, Naoshige
Subjects: Animals ; Biological and medical sciences ; Channelrhodopsins ; Chemical properties ; Cues ; Dopamine ; Dopamine - metabolism ; Dopaminergic Neurons - metabolism ; Fundamental and applied biological sciences. Psychology ; GABAergic Neurons - metabolism ; gamma-Aminobutyric Acid - metabolism ; Laboratory animals ; Light ; Male ; Mice ; Mice, Inbred C57BL ; Neurons ; Odorants - analysis ; Physiological aspects ; Principal Component Analysis ; Principal components analysis ; Properties ; Psychological aspects ; Punishment ; Reward ; Ventral tegmental area ; Ventral Tegmental Area - cytology ; Ventral Tegmental Area - physiology ; Vertebrates: nervous system and sense organs
Is Part Of: Nature (London), 2012-02, Vol.482 (7383), p.85-88
Description: Dopamine has a central role in motivation and reward. Dopaminergic neurons in the ventral tegmental area (VTA) signal the discrepancy between expected and actual rewards (that is, reward prediction error), but how they compute such signals is unknown. We recorded the activity of VTA neurons while mice associated different odour cues with appetitive and aversive outcomes. We found three types of neuron based on responses to odours and outcomes: approximately half of the neurons (type I, 52%) showed phasic excitation after reward-predicting odours and rewards in a manner consistent with reward prediction error coding; the other half of neurons showed persistent activity during the delay between odour and outcome that was modulated positively (type II, 31%) or negatively (type III, 18%) by the value of outcomes. Whereas the activity of type I neurons was sensitive to actual outcomes (that is, when the reward was delivered as expected compared to when it was unexpectedly omitted), the activity of type II and type III neurons was determined predominantly by reward-predicting odours. We 'tagged' dopaminergic and GABAergic neurons with the light-sensitive protein channelrhodopsin-2 and identified them based on their responses to optical stimulation while recording. All identified dopaminergic neurons were of type I and all GABAergic neurons were of type II. These results show that VTA GABAergic neurons signal expected reward, a key variable for dopaminergic neurons to calculate reward prediction error.
Publisher: London: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/nature10754
PMID: 22258508
CODEN: NATUAS
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

2015 INIST-CNRS ;COPYRIGHT 2012 Nature Publishing Group ;COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Feb 2, 2012 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature10754 ;PMID: 22258508 ;CODEN: NATUAS

Searching Remote Databases, Please Wait