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Gut inflammation provides a respiratory electron acceptor for Salmonella

Nature (London), 2010-09, Vol.467 (7314), p.426-429 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2010 Nature Publishing Group ;COPYRIGHT 2010 Nature Publishing Group ;Copyright Nature Publishing Group Sep 23, 2010 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature09415 ;PMID: 20864996 ;CODEN: NATUAS

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Title:
Gut inflammation provides a respiratory electron acceptor for Salmonella
Author: Bäumler, Andreas J ; Winter, Sebastian E ; Thiennimitr, Parameth ; Winter, Maria G ; Butler, Brian P ; Huseby, Douglas L ; Crawford, Robert W ; Russell, Joseph M ; Bevins, Charles L ; Adams, L. Garry ; Tsolis, Renée M ; Roth, John R
Subjects: Animals ; Bacteria ; Bacteriology ; Biological and medical sciences ; Cell Respiration ; Colitis - metabolism ; Colitis - microbiology ; Colorectal diseases ; Development and progression ; Electron Transport ; Electrons ; Female ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal diseases ; Gastrointestinal Tract - metabolism ; Gastrointestinal Tract - microbiology ; Gastrointestinal Tract - pathology ; Genes ; Health aspects ; Inflammation ; Inflammation - metabolism ; Inflammation - microbiology ; Inflammation - pathology ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - microbiology ; Intestinal Mucosa - pathology ; Mice ; Mice, Inbred C57BL ; Microbiology ; Molecular and cellular biology ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Physiological aspects ; Proteins ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Rodents ; Salmonella ; Salmonella enterica ; Salmonella typhimurium ; Salmonella typhimurium - growth & development ; Salmonella typhimurium - metabolism ; Tetrathionic Acid - metabolism ; Thiosulfates - metabolism
Is Part Of: Nature (London), 2010-09, Vol.467 (7314), p.426-429
Description: Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation react with endogenous, luminal sulphur compounds (thiosulphate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to use tetrathionate as an electron acceptor produce a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen.
Publisher: London: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/nature09415
PMID: 20864996
CODEN: NATUAS
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection

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Gut inflammation provides a respiratory electron acceptor for Salmonella

2015 INIST-CNRS ;COPYRIGHT 2010 Nature Publishing Group ;COPYRIGHT 2010 Nature Publishing Group ;Copyright Nature Publishing Group Sep 23, 2010 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature09415 ;PMID: 20864996 ;CODEN: NATUAS

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