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Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Cell, 2008-01, Vol.132 (2), p.171-176
[Peer Reviewed Journal]
2008 Elsevier Inc. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2008.01.007 ;PMID: 18243090
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Title:
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Author:
Guarente, Leonard
Subjects:
Aging
;
Animals
;
Caloric Restriction
;
Humans
;
Mitochondria - physiology
;
Models, Biological
;
Sirtuins
Is Part Of:
Cell, 2008-01, Vol.132 (2), p.171-176
Description:
Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.
Publisher:
United States: Elsevier Inc
Language:
English
Identifier:
ISSN: 0092-8674
EISSN: 1097-4172
DOI: 10.1016/j.cell.2008.01.007
PMID: 18243090
Source:
MEDLINE
Open Access: Cell Press Free Archives
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