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Impact of Extracranial Contamination on Regional Cerebral Oxygen Saturation: A Comparison of Three Cerebral Oximetry Technologies

Anesthesiology (Philadelphia), 2012-04, Vol.116 (4), p.834-840 [Peer Reviewed Journal]

2015 INIST-CNRS ;ISSN: 0003-3022 ;EISSN: 1528-1175 ;DOI: 10.1097/ALN.0b013e31824c00d7 ;PMID: 22343469 ;CODEN: ANESAV

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  • Title:
    Impact of Extracranial Contamination on Regional Cerebral Oxygen Saturation: A Comparison of Three Cerebral Oximetry Technologies
  • Author: DAVIE, Sophie N ; GROCOTT, Hilary P
  • Subjects: Adult ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Brain - blood supply ; Brain - metabolism ; Female ; Humans ; Hypoxia-Ischemia, Brain - diagnosis ; Hypoxia-Ischemia, Brain - metabolism ; Male ; Medical sciences ; Oximetry - methods ; Oximetry - standards ; Oxygen - metabolism ; Oxygen Consumption - physiology ; Spectroscopy, Near-Infrared - methods ; Spectroscopy, Near-Infrared - standards ; Young Adult
  • Is Part Of: Anesthesiology (Philadelphia), 2012-04, Vol.116 (4), p.834-840
  • Description: Cerebral oximetry is a noninvasive technology using near-infrared spectroscopy (NIRS) to estimate regional cerebral oxygen saturation. Although NIRS cerebral oximetry is being increasingly used in many clinical settings, interdevice technologic differences suggest potential variation in the ability to accurately acquire brain oxygenation signals. The primary objective of this study was to determine if NIRS-derived regional cerebral oxygen saturation measurements accurately account for oxygen saturation contamination from extracranial tissue. Twelve healthy volunteers had each of three NIRS devices (FORE-SIGHT [CAS Medical Systems Inc; Brandford, CT], INVOS 5100C-PB [Covidien; Boulder, CO], and EQUANOX Classic 7600 [Nonin Medical Inc; Plymouth, MN]) randomly applied to the forehead. After this, a circumferential pneumatic head cuff was positioned such that when inflated, hypoxia-ischemia would be produced in the extracranial scalp tissue beneath the NIRS cerebral oximeters. Comparisons among the three devices were made of the NIRS measurements before and following hypoxia-ischemia produced in the scalp tissue with inflation of the head cuff. The induction of extracranial hypoxia-ischemia resulted in a significant reduction in regional cerebral oxygen saturation measurements in all three NIRS devices studied. At 5 min postinflation of the pneumatic head cuff, the INVOS demonstrated a 16.6 ± 9.6% (mean ± SD) decrease from its baseline (P = 0.0001), the FORE-SIGHT an 11.8 ± 5.3% decrease from its baseline (P < 0.0001), and the EQUANOX a 6.8 ± 6.0% reduction from baseline (P = 0.0025). Extracranial contamination appears to significantly affect NIRS measurements of cerebral oxygen saturation. Although the clinical implications of these apparent inaccuracies require further study, they suggest that the oxygen saturation measurements provided by cerebral oximetry do not solely reflect that of the brain alone.
  • Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
  • Language: English
  • Identifier: ISSN: 0003-3022
    EISSN: 1528-1175
    DOI: 10.1097/ALN.0b013e31824c00d7
    PMID: 22343469
    CODEN: ANESAV
  • Source: MEDLINE
    Alma/SFX Local Collection
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