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The nuclear factor NF-kappaB pathway in inflammation

Cold Spring Harbor perspectives in biology, 2009-12, Vol.1 (6), p.a001651-a001651 [Peer Reviewed Journal]

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Title:
The nuclear factor NF-kappaB pathway in inflammation
Author: Lawrence, Toby
Subjects: Animals ; Gene Expression Regulation - physiology ; Inflammation - metabolism ; Mice ; NF-kappa B - genetics ; NF-kappa B - metabolism ; Signal Transduction - physiology
Is Part Of: Cold Spring Harbor perspectives in biology, 2009-12, Vol.1 (6), p.a001651-a001651
Description: The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.
Publisher: United States
Language: English
Identifier: EISSN: 1943-0264
DOI: 10.1101/cshperspect.a001651
PMID: 20457564
Source: Geneva Foundation Free Medical Journals at publisher websites
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PubMed Central
Alma/SFX Local Collection

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