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Humanized mice in translational biomedical research

Nature Reviews: Immunology, 2007-02, Vol.7 (2), p.118-130 [Peer Reviewed Journal]

COPYRIGHT 2007 Nature Publishing Group ;Copyright Nature Publishing Group Feb 2007 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;EISSN: 1365-2567 ;DOI: 10.1038/nri2017 ;PMID: 17259968

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Title:
Humanized mice in translational biomedical research
Author: Shultz, Leonard D ; Ishikawa, Fumihiko ; Greiner, Dale L
Subjects: Animals ; Chimera - genetics ; Chimera - immunology ; Communicable Diseases - immunology ; Disease Models, Animal ; Ethical aspects ; Genetic aspects ; Hematopoiesis ; Hematopoiesis - immunology ; Humans ; Immune response ; Medical research ; Medicine, Experimental ; Mice ; Mice, Knockout - genetics ; Mice, Knockout - immunology ; Mice, SCID - genetics ; Mice, SCID - immunology ; Mice, Transgenic - genetics ; Mice, Transgenic - immunology ; Neoplasms - immunology ; Physiological aspects
Is Part Of: Nature Reviews: Immunology, 2007-02, Vol.7 (2), p.118-130
Description: The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1733
EISSN: 1474-1741
EISSN: 1365-2567
DOI: 10.1038/nri2017
PMID: 17259968
Source: Geneva Foundation Free Medical Journals at publisher websites
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Humanized mice in translational biomedical research

COPYRIGHT 2007 Nature Publishing Group ;Copyright Nature Publishing Group Feb 2007 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;EISSN: 1365-2567 ;DOI: 10.1038/nri2017 ;PMID: 17259968

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