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ESEM evaluations of muscle/nanoparticles interface in a rat model

Journal of materials science. Materials in medicine, 2008-04, Vol.19 (4), p.1515-1522 [Peer Reviewed Journal]

Springer Science+Business Media, LLC 2008 ;ISSN: 0957-4530 ;EISSN: 1573-4838 ;DOI: 10.1007/s10856-008-3385-6 ;PMID: 18266087

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Title:
ESEM evaluations of muscle/nanoparticles interface in a rat model
Author: Gatti, Antonietta M. ; Kirkpatrick, James ; Gambarelli, Andrea ; Capitani, Federico ; Hansen, Torsten ; Eloy, Rosy ; Clermont, Gaelle
Subjects: Animals ; Biomaterials ; Biomedical engineering ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Carbon - chemistry ; Ceramics ; Chemistry and Materials Science ; Cobalt - chemistry ; Composites ; Diffusion ; Glass ; Materials Science ; Materials Testing ; Metal Nanoparticles - chemistry ; Metals - chemistry ; Microscopy, Electron, Scanning - methods ; Muscles - drug effects ; Muscles - metabolism ; Muscles - ultrastructure ; Nanoparticles - chemistry ; Nanotechnology ; Nanotechnology - methods ; Natural Materials ; Nickel - chemistry ; Polymer Sciences ; Rats ; Regenerative Medicine/Tissue Engineering ; Rodents ; Silicon Dioxide - chemistry ; Surfaces and Interfaces ; Thin Films ; Titanium - chemistry ; Transplants & implants
Is Part Of: Journal of materials science. Materials in medicine, 2008-04, Vol.19 (4), p.1515-1522
Description: In order to examine the influence that shape and chemistry of different materials have on the incitement of a tissue reaction, we implanted five materials (the two metals Ni and Co, the two ceramics TiO 2 and SiO 2 , and the polymer poly vinyl-chloride) as nanoparticles or bulk, in the dorsal muscles of 50 rats. After 6 or 12 months, rats were euthanized and the implanted materials were excised together with the surrounding tissue. After a first histological evaluation, the specimens were prepared for environmental scanning electron microscopy (ESEM) and for energy dispersive spectroscopy (EDS), in order to analyse the chemical composition of the implanted material after the biological interaction had occurred, and to evaluate the possible corrosion and diffusion of the materials at tissue interface. The results indicate that the metals at nanoscale size have a carcinogenic effect, while the bulk materials only induce a foreign-body reaction. The ESEM observations show a chemical transformation of the materials. Corrosion of the metals and subsequent recombination of the released ions in a sort of organic–inorganic crystals is showed and verified by the EDS analyses. Finally, our hypotheses of the involved pathological mechanism are suggested.
Publisher: Boston: Springer US
Language: English
Identifier: ISSN: 0957-4530
EISSN: 1573-4838
DOI: 10.1007/s10856-008-3385-6
PMID: 18266087
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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ESEM evaluations of muscle/nanoparticles interface in a rat model

Springer Science+Business Media, LLC 2008 ;ISSN: 0957-4530 ;EISSN: 1573-4838 ;DOI: 10.1007/s10856-008-3385-6 ;PMID: 18266087

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