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Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Nature immunology, 2020-01, Vol.21 (1), p.17-29 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2020 ;ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/s41590-019-0556-1 ;PMID: 31819255

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Title:
Regulation of cGAS- and RLR-mediated immunity to nucleic acids
Author: Ablasser, Andrea ; Hur, Sun
Subjects: Acids ; Adaptor Proteins, Signal Transducing - metabolism ; Amino acids ; Cells ; DEAD Box Protein 58 - metabolism ; Deoxyribonucleic acid ; DNA ; DNA - immunology ; Host-Pathogen Interactions - immunology ; Humans ; HuR protein ; Immunity, Innate - immunology ; Membrane Proteins - metabolism ; Nucleic acids ; Nucleotidyltransferases - metabolism ; Receptors, Immunologic ; Ribonucleic acid ; RNA ; RNA - immunology ; Signal Transduction - immunology
Is Part Of: Nature immunology, 2020-01, Vol.21 (1), p.17-29
Description: Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detection of cytosolic nucleic acid species, one of the most prominent being the cGAS-STING pathway for DNA and the RLR-MAVS pathway for RNA, respectively. Recent advances have revealed a plethora of regulatory mechanisms that are crucial for balancing the activity of nucleic acid sensors for the maintenance of overall cellular homeostasis. Elucidation of the various mechanisms that enable cells to maintain control over the activity of cytosolic nucleic acid sensors has provided new insight into the pathology of human diseases and, at the same time, offers a rich and largely unexplored source for new therapeutic targets. This Review addresses the emerging literature on regulation of the sensing of cytosolic DNA and RNA via cGAS and RLRs.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1529-2908
EISSN: 1529-2916
DOI: 10.1038/s41590-019-0556-1
PMID: 31819255
Source: MEDLINE
ProQuest Central

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Regulation of cGAS- and RLR-mediated immunity to nucleic acids

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2020 ;ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/s41590-019-0556-1 ;PMID: 31819255

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