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Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine

Nature reviews. Molecular cell biology, 2019-04, Vol.20 (4), p.211-226 [Peer Reviewed Journal]

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Apr 2019 ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/s41580-018-0086-y ;PMID: 30546055

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Title:
Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine
Author: Moya, Iván M ; Halder, Georg
Subjects: Activation ; Adaptor Proteins, Signal Transducing - metabolism ; Animals ; Cancer ; Cell adhesion & migration ; Cell cycle ; Cell growth ; Cellular signal transduction ; Cooperation ; Developmental plasticity ; Gene expression ; Growth factors ; Heart ; Humans ; Intestine ; Kinases ; Liver ; Medicine ; Mice ; Organs ; Organs (Anatomy) ; Phosphorylation ; Protein Serine-Threonine Kinases - metabolism ; Proteins ; Regeneration (physiology) ; Regenerative medicine ; Regenerative Medicine - methods ; RNA polymerase ; Side effects ; Signal transduction ; Signal Transduction - physiology ; Signaling ; Transcription factors ; Transcription Factors - metabolism ; Yes-associated protein
Is Part Of: Nature reviews. Molecular cell biology, 2019-04, Vol.20 (4), p.211-226
Description: The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), regulate organ growth and cell plasticity during animal development and regeneration. Remarkably, experimental activation of YAP/TAZ in the mouse can promote regeneration in organs with poor or compromised regenerative capacity, such as the adult heart and the liver and intestine of old or diseased mice. However, therapeutic YAP/TAZ activation may cause serious side effects. Most notably, YAP/TAZ are hyperactivated in human cancers, and prolonged activation of YAP/TAZ triggers cancer development in mice. Thus, can the power of YAP/TAZ to promote regeneration be harnessed in a safe way? Here, we review the role of Hippo signalling in animal regeneration, examine the promises and risks of YAP/TAZ activation for regenerative medicine and discuss strategies to activate YAP/TAZ for regenerative therapy while minimizing adverse side effects.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/s41580-018-0086-y
PMID: 30546055
Source: MEDLINE
ProQuest Central

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Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Apr 2019 ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/s41580-018-0086-y ;PMID: 30546055

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