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Nanopathology and its applications within the forensic discipline

Forensic science international, 2018-11, Vol.292, p.e16-e19 [Peer Reviewed Journal]

2018 Elsevier B.V. ;Copyright © 2018 Elsevier B.V. All rights reserved. ;Copyright Elsevier Limited Nov 2018 ;ISSN: 0379-0738 ;EISSN: 1872-6283 ;DOI: 10.1016/j.forsciint.2018.09.029 ;PMID: 30342921

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Title:
Nanopathology and its applications within the forensic discipline
Author: Roncati, Luca ; Gatti, Antonietta Morena ; Roncati, Monica ; Manenti, Antonio
Subjects: Autocrine signalling ; Biocompatibility ; Bone marrow ; Causality ; Criminal investigations ; Criminal law ; Deeds ; Deoxyribonucleic acid ; Diagnostic tests ; Diseases ; DNA ; DNA damage ; Endocrine disruptors ; Energy-dispersive X-ray spectroscopy (EDX) ; Entrances ; Environmental Exposure - adverse effects ; Environmental scanning electron microscope (ESEM) ; Exposure ; Foreign Bodies - pathology ; Forensic Pathology ; Forensic science ; Forensic sciences ; Humans ; Industrial pollution ; Inhalation ; Interdisciplinary aspects ; Intestinal absorption ; Intestine ; Irritation ; Microscopy ; Microscopy, Electron, Scanning ; Military personnel ; Nanoparticles ; Nanoparticles - toxicity ; Nanoparticles - ultrastructure ; Nanopathology ; Nanotoxicology ; Occupational Exposure - adverse effects ; Paracrine signalling ; Particulate matter ; Persian Gulf War ; Respiration ; Spectrometry, X-Ray Emission ; Streams ; Translocation ; Tumorigenesis
Is Part Of: Forensic science international, 2018-11, Vol.292, p.e16-e19
Description: •Nanopathology is an ultra-specialized branch of pathological anatomy.•It is aimed to detect inorganic nanoparticles inside pathological tissues.•It is useful for to identify pathogenic nanoparticles inside foreign-body granuloma.•It serves to attest occupational diseases burdened by exposure risk.•It allows to ascertain a causal link between pathology and harmful past exposure. The impact of nanopathology in medicine necessarily involves also the anatomo-pathological diagnostics, because of the current large spread of nanoparticles in the environment and the wide spectrum of correlated human diseases. The main entrance gates of nanoparticles into the body are respiratory inhalation, gastro-intestinal absorption and injection of polluted drugs. In all these cases, their penetration in the lymphatic or blood streams are possible, with subsequent systemic translocation. Different diseases can be generated by nanoparticles exposure, from a direct contact irritation to the onset of granulomatous diseases. Interestingly, they can also act as endocrine disruptors on the autocrine and paracrine systems. At cellular level, nanoparticles can damage the DNA content leading to a subsequent tumorigenesis. In the forensic setting, they can be searched in case of known exposure to inorganic particulate matter or in case of diseases of unknown origin, from granulomatous reactions to foreign inclusions in neoplastic tissues. The combined physical-histopathological studies allow to relate possible environmental/industrial pollution with the pathology and offer a novel tool for forensic investigations, but, overall, they represent new technical evidences for lawyers to present in a court.
Publisher: Ireland: Elsevier B.V
Language: English
Identifier: ISSN: 0379-0738
EISSN: 1872-6283
DOI: 10.1016/j.forsciint.2018.09.029
PMID: 30342921
Source: AUTh Library subscriptions: ProQuest Central
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Nanopathology and its applications within the forensic discipline

2018 Elsevier B.V. ;Copyright © 2018 Elsevier B.V. All rights reserved. ;Copyright Elsevier Limited Nov 2018 ;ISSN: 0379-0738 ;EISSN: 1872-6283 ;DOI: 10.1016/j.forsciint.2018.09.029 ;PMID: 30342921

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