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Lactic Acid: No Longer an Inert and End-Product of Glycolysis

Physiology (Bethesda, Md.), 2017-11, Vol.32 (6), p.453-463 [Peer Reviewed Journal]

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Title:
Lactic Acid: No Longer an Inert and End-Product of Glycolysis
Author: Sun, Shiren ; Li, Heng ; Chen, Jianghua ; Qian, Qi
Subjects: Animals ; Glycolysis - physiology ; Humans ; Lactic Acid - metabolism ; Monocarboxylic Acid Transporters - metabolism ; Receptors, G-Protein-Coupled - metabolism ; Signal Transduction - physiology
Is Part Of: Physiology (Bethesda, Md.), 2017-11, Vol.32 (6), p.453-463
Description: For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.
Publisher: United States
Language: English
Identifier: ISSN: 1548-9213
EISSN: 1548-9221
DOI: 10.1152/physiol.00016.2017
PMID: 29021365
Source: MEDLINE
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