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Cardiovascular and gill microcirculatory effects of endothelin-1 in atlantic cod: evidence for pillar cell contraction

Journal of experimental biology, 1999-05, Vol.202 (Pt 9) (9), p.1151-1157 [Peer Reviewed Journal]

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Title:
Cardiovascular and gill microcirculatory effects of endothelin-1 in atlantic cod: evidence for pillar cell contraction
Author: Stenslokken, KO ; Sundin, L ; Nilsson, GE
Is Part Of: Journal of experimental biology, 1999-05, Vol.202 (Pt 9) (9), p.1151-1157
Description: Endothelin-1 (ET-1) has been shown to cause a considerable increase in the vascular resistance of fish gills. In trout, recent evidence suggest that this is the result of pillar cell contraction in the gill lamellae. Using epi-illumination microscopy to observe the gill lamellae of anaesthetised Atlantic cod (Gadus morhua), we show that ET-1 (100 ng kg-1, injected into the ventral aorta) causes an increase in pillar cell diameter, consistent with pillar cell contraction, and a shift of intralamellar blood flow from the lamellar sheet to the outer marginal channels. Simultaneously, there was an increase in ventral aortic blood pressure, a reduction in cardiac output, an increase in gill vascular resistance and a reduction in the oxygen partial pressure of venous blood. All these effects were blocked by the ETA/ETB receptor antagonist bosentan (5 mg kg-1). Pillar cell contraction is likely to be a mechanism for matching the functional respiratory surface area with the instantaneous respiratory needs of the fish.
Publisher: England
Language: English
Identifier: ISSN: 0022-0949
EISSN: 1477-9145
DOI: 10.1242/jeb.202.9.1151
PMID: 10101112
Source: GFMER Free Medical Journals

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