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The Precision Medicine Initiative's All of Us Research Program: an agenda for research on its ethical, legal, and social issues

Genetics in medicine, 2017-07, Vol.19 (7), p.743-750 [Peer Reviewed Journal]

Copyright Nature Publishing Group Jul 2017 ;ISSN: 1098-3600 ;EISSN: 1530-0366 ;DOI: 10.1038/gim.2016.183 ;PMID: 27929525

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  • Title:
    The Precision Medicine Initiative's All of Us Research Program: an agenda for research on its ethical, legal, and social issues
  • Author: Sankar, Pamela L ; Parker, Lisa S
  • Subjects: Ethics, Research ; Humans ; Longitudinal Studies ; Morals ; National Institutes of Health (U.S.) ; Precision Medicine - ethics ; Precision Medicine - methods ; Privacy ; United States
  • Is Part Of: Genetics in medicine, 2017-07, Vol.19 (7), p.743-750
  • Description: The Precision Medicine Initiative (PMI) is an innovative approach to developing a new model of health care that takes into account individual differences in people's genes, environments, and lifestyles. A cornerstone of the initiative is the PMI All of Us Research Program (formerly known as PMI-Cohort Program) which will create a cohort of 1 million volunteers who will contribute their health data and biospecimens to a centralized national database to support precision medicine research. The PMI All of US Research Program is the largest longitudinal study in the history of the United States. The designers of the Program anticipated and addressed some of the ethical, legal, and social issues (ELSI) associated with the initiative. To date, however, there is no plan to call for research regarding ELSI associated with the Program-PMI All of Us program. Based on analysis of National Institutes of Health (NIH) funding announcements for the PMI All of Us program, we have identified three ELSI themes: cohort diversity and health disparities, participant engagement, and privacy and security. We review All of Us Research Program plans to address these issues and then identify additional ELSI within each domain that warrant ongoing investigation as the All of Us Research Program develops. We conclude that PMI's All of Us Research Program represents a significant opportunity and obligation to identify, analyze, and respond to ELSI, and we call on the PMI to initiate a research program capable of taking on these challenges.Genet Med advance online publication 01 December 2016.
  • Publisher: United States: Elsevier Limited
  • Language: English
  • Identifier: ISSN: 1098-3600
    EISSN: 1530-0366
    DOI: 10.1038/gim.2016.183
    PMID: 27929525
  • Source: MEDLINE
    ProQuest Central
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