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Diosbulbin B-induced liver injury in mice and its mechanism

Human & experimental toxicology, 2014-07, Vol.33 (7), p.729-736 [Peer Reviewed Journal]

The Author(s) 2014 ;2015 INIST-CNRS ;The Author(s) 2014. ;SAGE Publications © Jul 2014 ;ISSN: 0960-3271 ;EISSN: 1477-0903 ;DOI: 10.1177/0960327113506232 ;PMID: 24107456

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Title:
Diosbulbin B-induced liver injury in mice and its mechanism
Author: Ma, Yibo ; Niu, Chengwei ; Wang, Junming ; Ji, Lili ; Wang, Zhengtao
Subjects: Administration, Oral ; Alanine Transaminase - blood ; Alkaline Phosphatase - blood ; Animals ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Biomarkers - blood ; Chemical and Drug Induced Liver Injury - blood ; Chemical and Drug Induced Liver Injury - enzymology ; Chemical and Drug Induced Liver Injury - etiology ; Chemical and Drug Induced Liver Injury - genetics ; Chemical and Drug Induced Liver Injury - pathology ; Dioscorea bulbifera ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - toxicity ; Flowers & plants ; Gene Expression Regulation, Enzymologic ; General pharmacology ; Glutathione - metabolism ; Hepatology ; Heterocyclic Compounds, 4 or More Rings - administration & dosage ; Heterocyclic Compounds, 4 or More Rings - toxicity ; Liver - drug effects ; Liver - enzymology ; Liver - pathology ; Liver diseases ; Male ; Malondialdehyde - metabolism ; Medical sciences ; Mice, Inbred ICR ; Oxidative Stress - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; RNA, Messenger - metabolism ; Rodents ; Time Factors ; Toxicity ; Toxicology
Is Part Of: Human & experimental toxicology, 2014-07, Vol.33 (7), p.729-736
Description: Dioscorea bulbifera L., a commonly used medicinal plant in China, is reported to induce hepatotoxicity. The present study is undertaken to investigate the hepatotoxicity induced by diosbulbin B (DB), a diterpene lactone isolated from D. bulbifera L., and to further explore its underlying mechanism. DB was administered to mice at the doses of 0, 16, 32, and 64 mg/kg once daily for 12 consecutive days. Liver injury induced by DB was evidenced by the increased activity of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Liver histological evaluation showed that the mice treated with DB exhibited liver damage with the swelling of hepatocytes. Further results showed that the amount of malondialdehyde (MDA) in the liver was increased in mice treated with DB, while the glutathione amount and the enzymatic activity of glutathione peroxidase (GPx), glutathione-S-transferase (GST), copper/zinc–superoxide dismutase (CuZn-SOD), manganese-SOD (Mn-SOD), and catalase (CAT) were all decreased. DB also decreased the gene expression of CuZn-SOD and CAT. Taken together, our results indicate that oral administration of DB for 12 consecutive days can lead to the oxidative stress liver injury in mice.
Publisher: London, England: SAGE Publications
Language: English
Identifier: ISSN: 0960-3271
EISSN: 1477-0903
DOI: 10.1177/0960327113506232
PMID: 24107456
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
ProQuest Central

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Diosbulbin B-induced liver injury in mice and its mechanism

The Author(s) 2014 ;2015 INIST-CNRS ;The Author(s) 2014. ;SAGE Publications © Jul 2014 ;ISSN: 0960-3271 ;EISSN: 1477-0903 ;DOI: 10.1177/0960327113506232 ;PMID: 24107456

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